Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors

Gordon Keller, Christopher Paige, Eli Gilboa, Erwin F. Wagner

Research output: Contribution to journalArticle

325 Scopus citations

Abstract

Bone marrow cells infected with retroviral vectors carrying the bacterial neomycin resistance (neo) gene as a marker were used for long-term reconstitution of the haematopoietic system of irradiated mice. The neo gene is expressed in the myeloid and lymphoid lineages of these animals and an analysis of the sites of viral integration indicates that these lineages are derived from the same primitive multipotent cells.

Original languageEnglish (US)
Pages (from-to)149-154
Number of pages6
JournalNature
Volume318
Issue number6042
DOIs
StatePublished - Dec 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors'. Together they form a unique fingerprint.

  • Cite this