Expression of a ClC chloride channel in Caenorhabditis elegans gamma-aminobutyric acid-ergic neurons

Laura Bianchi, David M. Miller, Alfred L. George

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this study, we report the complete cDNA sequence, genomic organization and expression pattern of the Caenorhabditis elegans ClC chloride channel gene, clh-6. Two different types of reporter gene fusions suggest that clh-6 expression is restricted to two gamma-aminobutyric acid-ergic RME neurons. These results are in striking contrast with the wide tissue distribution of messenger RNA for the related mammalian isoforms, ClC-6 and ClC-7. The restricted expression pattern of clh-6 provides a unique opportunity to study the biological function of a neuronal ClC chloride channel.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalNeuroscience Letters
Volume299
Issue number3
DOIs
StatePublished - Feb 23 2001
Externally publishedYes

Fingerprint

Chloride Channels
Caenorhabditis elegans
gamma-Aminobutyric Acid
Neurons
Gene Fusion
Tissue Distribution
Reporter Genes
Protein Isoforms
Complementary DNA
Messenger RNA
Genes

Keywords

  • Caenorhabditis elegans
  • ClC channels
  • Gamma-aminobutyric acid-ergic neurons
  • Green fluorescent protein fusions

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Expression of a ClC chloride channel in Caenorhabditis elegans gamma-aminobutyric acid-ergic neurons. / Bianchi, Laura; Miller, David M.; George, Alfred L.

In: Neuroscience Letters, Vol. 299, No. 3, 23.02.2001, p. 177-180.

Research output: Contribution to journalArticle

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