Expression of a ClC chloride channel in Caenorhabditis elegans gamma-aminobutyric acid-ergic neurons

Laura Bianchi, David M. Miller, Alfred L. George

Research output: Contribution to journalArticle

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Abstract

In this study, we report the complete cDNA sequence, genomic organization and expression pattern of the Caenorhabditis elegans ClC chloride channel gene, clh-6. Two different types of reporter gene fusions suggest that clh-6 expression is restricted to two gamma-aminobutyric acid-ergic RME neurons. These results are in striking contrast with the wide tissue distribution of messenger RNA for the related mammalian isoforms, ClC-6 and ClC-7. The restricted expression pattern of clh-6 provides a unique opportunity to study the biological function of a neuronal ClC chloride channel.

Original languageEnglish (US)
Pages (from-to)177-180
Number of pages4
JournalNeuroscience Letters
Volume299
Issue number3
DOIs
StatePublished - Feb 23 2001
Externally publishedYes

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Keywords

  • Caenorhabditis elegans
  • ClC channels
  • Gamma-aminobutyric acid-ergic neurons
  • Green fluorescent protein fusions

ASJC Scopus subject areas

  • Neuroscience(all)

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