Expression cloning of a full-length cDNA encoding delta opioid receptor from mouse thymocytes

Mohamed Sedqi, Sabita Roy, Sundaram Ramakrishnan, Horace H. Loh

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

A delta opioid receptor complementary DNA (cDNA) was cloned by expression of cDNA library from activated thymocytes in Cos 7 cells. The deduced amino acid sequence of this receptor was similar to that described in the brain. As analyzed by southern blot hybridization, the delta opioid receptor transcripts are constitutively expressed in unactivated thymocytes. In addition, neither κ nor μ opioid receptor transcripts were detected in thymocytes, suggesting tissue-specific opioid receptor gene expression in the immune system. The studies represent the first report of a full-length opioid receptor in the immune system.

Original languageEnglish (US)
Pages (from-to)167-170
Number of pages4
JournalJournal of Neuroimmunology
Volume65
Issue number2
DOIs
StatePublished - Apr 1996
Externally publishedYes

Keywords

  • Delta opioid receptor
  • Immune cells
  • Thymocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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