Expression and functional analysis of murine ÇD30

S. Y. Nam, R. K. Lee, G. Miragliotta, Eckhard R Podack

Research output: Contribution to journalArticlepeer-review


CD30 expression and its possible signaling was studied in the murine system, focusing on lymphokine(LK) production. Balb/c lymph node(LN) cells activated with plate-bound anti-CD3 substantially expressed CD30 (15 and 60% after primary and secondary stimulation, respectively) and its expression was found on T cell, including both CD4+ and CDS+ cells, and non-T cell population. Activated LN cells in IL 4 (LN/IL 4) or IL 12 (LN/IL 12), which upregulated CD30 expression, were restimulated with anti-CD3 and/or antiCD30. Anti-CD30 alone showed minimal effect on LK production. However, by concurrent stimulation with anti-CD3, cross-linking of CD30 significantly upregulated Th2- type cytokine production of LN/IL 4, but not of LN/IL 12. These results indicate that CD30 may transduce crucial signal(s) in the polarized differentiation of Thl-Th2 cells depending on LK environment.

Original languageEnglish (US)
Pages (from-to)A1039
JournalFASEB Journal
Issue number6
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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