Exposure to low dose ionising radiation

Molecular and clinical consequences

Lynn M. Martin, Brian Marples, Thomas H. Lynch, Donal Hollywood, Laure Marignol

Research output: Contribution to journalComment/debate

18 Citations (Scopus)

Abstract

This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect.

Original languageEnglish (US)
Pages (from-to)98-106
Number of pages9
JournalCancer Letters
Volume349
Issue number1
DOIs
StatePublished - Jul 10 2014
Externally publishedYes

Fingerprint

Radiation Tolerance
Ionizing Radiation
Cell Cycle Checkpoints
DNA Repair
Radiation
Incidence

Keywords

  • Cell cycle arrest
  • DNA damage
  • Hypersensitivity
  • Ionising radiation
  • Low dose

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Exposure to low dose ionising radiation : Molecular and clinical consequences. / Martin, Lynn M.; Marples, Brian; Lynch, Thomas H.; Hollywood, Donal; Marignol, Laure.

In: Cancer Letters, Vol. 349, No. 1, 10.07.2014, p. 98-106.

Research output: Contribution to journalComment/debate

Martin, Lynn M. ; Marples, Brian ; Lynch, Thomas H. ; Hollywood, Donal ; Marignol, Laure. / Exposure to low dose ionising radiation : Molecular and clinical consequences. In: Cancer Letters. 2014 ; Vol. 349, No. 1. pp. 98-106.
@article{f5f52078e93f41f3a6a75ec7c3da844d,
title = "Exposure to low dose ionising radiation: Molecular and clinical consequences",
abstract = "This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect.",
keywords = "Cell cycle arrest, DNA damage, Hypersensitivity, Ionising radiation, Low dose",
author = "Martin, {Lynn M.} and Brian Marples and Lynch, {Thomas H.} and Donal Hollywood and Laure Marignol",
year = "2014",
month = "7",
day = "10",
doi = "10.1016/j.canlet.2013.12.015",
language = "English (US)",
volume = "349",
pages = "98--106",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Exposure to low dose ionising radiation

T2 - Molecular and clinical consequences

AU - Martin, Lynn M.

AU - Marples, Brian

AU - Lynch, Thomas H.

AU - Hollywood, Donal

AU - Marignol, Laure

PY - 2014/7/10

Y1 - 2014/7/10

N2 - This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect.

AB - This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect.

KW - Cell cycle arrest

KW - DNA damage

KW - Hypersensitivity

KW - Ionising radiation

KW - Low dose

UR - http://www.scopus.com/inward/record.url?scp=84901004801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901004801&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2013.12.015

DO - 10.1016/j.canlet.2013.12.015

M3 - Comment/debate

VL - 349

SP - 98

EP - 106

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -