Exposure to low dose ionising radiation: Molecular and clinical consequences

Lynn M. Martin, Brian Marples, Thomas H. Lynch, Donal Hollywood, Laure Marignol

Research output: Contribution to journalComment/debate

20 Scopus citations

Abstract

This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect.

Original languageEnglish (US)
Pages (from-to)98-106
Number of pages9
JournalCancer letters
Volume349
Issue number1
DOIs
StatePublished - Jul 10 2014
Externally publishedYes

Keywords

  • Cell cycle arrest
  • DNA damage
  • Hypersensitivity
  • Ionising radiation
  • Low dose

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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