Exploring the thyroid-skin connection

Concepts, questions, and clinical relevance

Research output: Contribution to journalComment/debate

31 Citations (Scopus)

Abstract

The thyroid-skin connection has become a hot frontier in dermatoendocrinology. In this context, the pituitary hormone that controls thyroid hormone production, thyrotropin (TSH), caught the attention of skin researchers only after it was reported that the receptor for TSH (TSH-R) is transcribed and translated by selected cultured human skin cell populations and in normal human scalp skin in situ, introducing skin as a nonconventional, peripheral target organ for regulation by TSH. In this issue, Cianfarani et al. present corroborating evidence and raise the old question of whether intracutaneous TSH-R stimulation by autoantibodies contributes to the skin changes seen in autoimmune thyroid disease. This provides a good opportunity to define the questions to be addressed when exploring the thyroid-skin connection.

Original languageEnglish (US)
Pages (from-to)7-10
Number of pages4
JournalJournal of Investigative Dermatology
Volume130
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Skin
Thyroid Gland
Thyrotropin Receptors
Pituitary Hormones
Thyroid Diseases
Thyrotropin
Scalp
Thyroid Hormones
Autoantibodies
Autoimmune Diseases
Cells
Research Personnel
Population

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Exploring the thyroid-skin connection : Concepts, questions, and clinical relevance. / Paus, Ralf.

In: Journal of Investigative Dermatology, Vol. 130, No. 1, 01.01.2010, p. 7-10.

Research output: Contribution to journalComment/debate

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