Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease

P. I. Lin, E. R. Martin, P. G. Bronson, C. Browning-Large, G. W. Small, D. E. Schmechel, K. A. Welsh-Bohmer, J. L. Haines, J. R. Gilbert, M. A. Pericak-Vance

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

BACKGROUND: Previous linkage studies have shown that chromosome 12 harbors susceptibility genes for late-onset Alzheimer disease (LOAD). However, association studies of several candidate genes on this chromosome region have produced ambiguous results. A recent study reported the association between the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene on chromosome 12p and the risk of LOAD. METHODS: The authors conducted family-based and case-control association studies in two independent LOAD data sets on 12 single-nucleotide polymorphisms (SNPs) in the GAPD gene and its paralogs. RESULTS: No association was found of the GAPD gene with LOAD in the family-based data set, but marginal evidence of association was seen in the later-onset subgroup when age at onset was stratified. The SNP rs2029721 in one GAPD pseudogene was also found to be associated with risk for LOAD in the unrelated case-control data set (p = 0.003). CONCLUSIONS: The GAPD gene and its pseudogene may play a role in the development of late-onset Alzheimer disease. However, the effect, if any, is likely to be limited.

Original languageEnglish (US)
Pages (from-to)64-68
Number of pages5
JournalNeurology
Volume67
Issue number1
DOIs
StatePublished - Jul 2006
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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