Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease

P. I. Lin, Eden R Martin, P. G. Bronson, C. Browning-Large, G. W. Small, D. E. Schmechel, K. A. Welsh-Bohmer, J. L. Haines, John Gilbert, Margaret A Pericak-Vance

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Abstract

BACKGROUND: Previous linkage studies have shown that chromosome 12 harbors susceptibility genes for late-onset Alzheimer disease (LOAD). However, association studies of several candidate genes on this chromosome region have produced ambiguous results. A recent study reported the association between the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene on chromosome 12p and the risk of LOAD. METHODS: The authors conducted family-based and case-control association studies in two independent LOAD data sets on 12 single-nucleotide polymorphisms (SNPs) in the GAPD gene and its paralogs. RESULTS: No association was found of the GAPD gene with LOAD in the family-based data set, but marginal evidence of association was seen in the later-onset subgroup when age at onset was stratified. The SNP rs2029721 in one GAPD pseudogene was also found to be associated with risk for LOAD in the unrelated case-control data set (p = 0.003). CONCLUSIONS: The GAPD gene and its pseudogene may play a role in the development of late-onset Alzheimer disease. However, the effect, if any, is likely to be limited.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalNeurology
Volume67
Issue number1
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

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Glyceraldehyde-3-Phosphate Dehydrogenases
Alzheimer Disease
Genes
Pseudogenes
Single Nucleotide Polymorphism
Chromosomes
Chromosomes, Human, Pair 12
Genetic Association Studies
Age of Onset
Case-Control Studies
Datasets

ASJC Scopus subject areas

  • Neuroscience(all)

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Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease. / Lin, P. I.; Martin, Eden R; Bronson, P. G.; Browning-Large, C.; Small, G. W.; Schmechel, D. E.; Welsh-Bohmer, K. A.; Haines, J. L.; Gilbert, John; Pericak-Vance, Margaret A.

In: Neurology, Vol. 67, No. 1, 01.07.2006, p. 64-68.

Research output: Contribution to journalArticle

Lin, PI, Martin, ER, Bronson, PG, Browning-Large, C, Small, GW, Schmechel, DE, Welsh-Bohmer, KA, Haines, JL, Gilbert, J & Pericak-Vance, MA 2006, 'Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease', Neurology, vol. 67, no. 1, pp. 64-68. https://doi.org/10.1212/01.wnl.0000223438.90113.4e
Lin, P. I. ; Martin, Eden R ; Bronson, P. G. ; Browning-Large, C. ; Small, G. W. ; Schmechel, D. E. ; Welsh-Bohmer, K. A. ; Haines, J. L. ; Gilbert, John ; Pericak-Vance, Margaret A. / Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease. In: Neurology. 2006 ; Vol. 67, No. 1. pp. 64-68.
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