Exploring human diseases and biological mechanisms by protein structure prediction and modeling

Juexin Wang, Joseph Luttrell, Ning Zhang, Saad Khan, Nian Qing Shi, Michael X. Wang, Jing Qiong Kang, Zheng Wang, Dong Xu

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Protein structure prediction and modeling provide a tool for understanding protein functions by computationally constructing protein structures from amino acid sequences and analyzing them. With help from protein prediction tools and web servers, users can obtain the three-dimensional protein structure models and gain knowledge of functions from the proteins. In this chapter, we will provide several examples of such studies. As an example, structure modeling methods were used to investigate the relation between mutation-caused misfolding of protein and human diseases including epilepsy and leukemia. Protein structure prediction and modeling were also applied in nucleotide-gated channels and their interaction interfaces to investigate their roles in brain and heart cells. In molecular mechanism studies of plants, rice salinity tolerance mechanism was studied via structure modeling on crucial proteins identified by systems biology analysis; traitassociated protein-protein interactions were modeled, which sheds some light on the roles of mutations in soybean oil/protein content. In the age of precision medicine, we believe protein structure prediction and modeling will play more and more important roles in investigating biomedical mechanism of diseases and drug design.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages39-61
Number of pages23
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume939
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Biological mechanism
  • GWAS
  • Human disease
  • Plant breeding
  • Protein misfolding
  • Protein structure modeling
  • Protein structure prediction
  • Sequence mutation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Wang, J., Luttrell, J., Zhang, N., Khan, S., Shi, N. Q., Wang, M. X., Kang, J. Q., Wang, Z., & Xu, D. (2016). Exploring human diseases and biological mechanisms by protein structure prediction and modeling. In Advances in Experimental Medicine and Biology (pp. 39-61). (Advances in Experimental Medicine and Biology; Vol. 939). Springer New York LLC. https://doi.org/10.1007/978-981-10-1503-8_3