Exploratory search during directed navigation in C. Elegans and drosophila larva

Mason Klein, Sergei V. Krivov, Anggie J. Ferrer, Linjiao Luo, Aravinthan D.T. Samuel, Martin Karplus

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Many organisms—from bacteria to nematodes to insect larvae—navigate their environments by biasing random movements. In these organisms, navigation in isotropic environments can be characterized as an essentially diffusive and undirected process. In stimulus gradients, movement decisions are biased to drive directed navigation toward favorable environments. How does directed navigation in a gradient modulate random exploration either parallel or orthogonal to the gradient? Here, we introduce methods originally used for analyzing protein folding trajectories to study the trajectories of the nematode Caenorhabditis elegans and the Drosophila larva in isotropic environments, as well as in thermal and chemical gradients. We find that the statistics of random exploration in any direction are little affected by directed movement along a stimulus gradient. A key constraint on the behavioral strategies of these organisms appears to be the preservation of their capacity to continuously explore their environments in all directions even while moving toward favorable conditions.

Original languageEnglish (US)
Article numbere30503
JournaleLife
Volume6
DOIs
StatePublished - Oct 30 2017

Fingerprint

Drosophila
Larva
Navigation
Trajectories
Protein folding
Bacteria
Statistics
Protein Folding
Caenorhabditis elegans
Insects
Hot Temperature
Direction compound

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Klein, M., Krivov, S. V., Ferrer, A. J., Luo, L., Samuel, A. D. T., & Karplus, M. (2017). Exploratory search during directed navigation in C. Elegans and drosophila larva. eLife, 6, [e30503]. https://doi.org/10.7554/eLife.30503

Exploratory search during directed navigation in C. Elegans and drosophila larva. / Klein, Mason; Krivov, Sergei V.; Ferrer, Anggie J.; Luo, Linjiao; Samuel, Aravinthan D.T.; Karplus, Martin.

In: eLife, Vol. 6, e30503, 30.10.2017.

Research output: Contribution to journalArticle

Klein, M, Krivov, SV, Ferrer, AJ, Luo, L, Samuel, ADT & Karplus, M 2017, 'Exploratory search during directed navigation in C. Elegans and drosophila larva', eLife, vol. 6, e30503. https://doi.org/10.7554/eLife.30503
Klein, Mason ; Krivov, Sergei V. ; Ferrer, Anggie J. ; Luo, Linjiao ; Samuel, Aravinthan D.T. ; Karplus, Martin. / Exploratory search during directed navigation in C. Elegans and drosophila larva. In: eLife. 2017 ; Vol. 6.
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