Exploiting localized surface binding effects to enhance the catalytic reactivity of peptide-capped nanoparticles

Ryan Coppage, Joseph M. Slocik, Hadi Ramezani-Dakhel, Nicholas M. Bedford, Hendrik Heinz, Rajesh R. Naik, Marc R. Knecht

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Peptide-based methods represent new approaches to selectively produce nanostructures with potentially important functionality. Unfortunately, biocombinatorial methods can only select peptides with target affinity and not for the properties of the final material. In this work, we present evidence to demonstrate that materials-directing peptides can be controllably modified to substantially enhance particle functionality without significantly altering nanostructural morphology. To this end, modification of selected residues to vary the site-specific binding strength and biological recognition can be employed to increase the catalytic efficiency of peptide-capped Pd nanoparticles. These results represent a step toward the de novo design of materials-directing peptides that control nanoparticle structure/function relationships.

Original languageEnglish (US)
Pages (from-to)11048-11054
Number of pages7
JournalJournal of the American Chemical Society
Volume135
Issue number30
DOIs
StatePublished - Jul 31 2013

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint

Dive into the research topics of 'Exploiting localized surface binding effects to enhance the catalytic reactivity of peptide-capped nanoparticles'. Together they form a unique fingerprint.

Cite this