Expert consensus on ceramides containing skincare in newborns and infants and potential mitigation of atopic dermatitis

Lawrence A. SCHACHNER, Ulrike BLUME-PEYTAVI, Anneke ANDRIESSEN, Jan Izakovic, Annabel MARUANI, Giuseppe MICALI, Nikolay MURASHKIN, Carmen SALAVASTRU, Antonio TORRELO

Research output: Contribution to journalReview articlepeer-review


INTRODUCTION: The vulnerable skin of neonates and infants is still developing anatomically and functionally and more susceptible to skin barrier disruption. The current consensus paper explores challenges in caring for neonates and infants' skin, skincare use and evaluates the role of ceramides (CERs) containing cleansers and moisturizers. EVIDENCEAQUISITION: Apanel of eight clinicians who treat neonates and infants developed a consensus paper on new-born and infant skin barrier integrity and CERs-containing skincare importance. The consensus process consisted of a modified Delphi technique. The selected information from the literature searches, coupled with the panel's opinion and experience, was used to adopt statements to provide clinical data for pediatric dermatologists, dermatologists, and pediatric healthcare providers who treat neonates and infants. EVIDENCE SYNTHESIS: Increasingly, evidence supports skincare starting early in life, recognizing the benefits of ongoing daily use of non-alkaline cleansers and moisturizers to maintain skin barrier function. Skincare for neonates and infants should be safe, effective, and fragrance as well as sensitizing agent-free. Skincare with CERs may benefit the stratum corneum's lipid and water content. CONCLUSIONS: When applied from birth onwards, gentle cleansers and moisturizers containing barrier lipids help maintain the protective skin barrier and soothe the skin with long-term moisturizing benefits.

Original languageEnglish (US)
Pages (from-to)23-32
Number of pages10
JournalItalian Journal of Dermatology and Venereology
Issue number1
StatePublished - Feb 2022
Externally publishedYes


  • Ceramides
  • Newborn infant
  • Skin care

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases
  • Medicine(all)


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