Experimentally-induced diabetes reduces nocturnal pineal melatonin content in the Syrian hamster

Thomas H. Champney, George C. Brainard, Bruce A. Richardson, Russel J. Reiter

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

1. 1. Male, Syrian hamsters were rendered diabetic by either alloxan (60mg/kg, i.v.) or streptozotocin (65 mg/kg, i.p.). 2. 2. Diabetic animals had reduced pineal melatonin contents during the night. Basal daytime values were not significantly altered. 3. 3. Diabetes may decrease melatonin synthesis by reducing the availability of glucose for metabolism or by decreasing the transport of tryptophan into pinealocytes for the synthesis of melatonin.

Original languageEnglish (US)
Pages (from-to)199-201
Number of pages3
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume76
Issue number1
DOIs
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Physiology

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