Experimental spinal cord injury: Mr correlation to intensity of injury

David B. Hackney, John C. Ford, Ronald S. Markowitz, Christopher M. Hand, Peter M. Joseph, Perry Black

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Objective: This study was conducted to determine the association between lesion length measured on MRI and the severity of mechanical injury in a rat model of spinal cord trauma.Materials and Methods: Sprague-Dawley rats were subjected to a modified Allen weight drop injury and killed 4 h after injury. Their fixed, excised cords were studied with MRI at 1.9 T. Results: There were strong correlations between lesion length on MR images and weight drop height and square root of drop height (r2= 0.55, p < 0.0001 and r2= 0.63, p < 0.0001, respectively). The lesion length differences were significant versus controls for all drop heights at p values of ≤0.002 and for the 2.5 cm animals versus the 5 and 15 cm animals (p = 0.01 and p = 0.0002, respectively), but the lengths of the 5 vs. 15 cm groups only approached significance (p = 0.06). Conclusion: These results suggest that lesion length determined on MR images is a reliable indicator of the severity of trauma among animals subjected to weight drop injury.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalJournal of computer assisted tomography
Volume18
Issue number3
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Keywords

  • Magnetic resonance imaging
  • Spinal cord wounds and injuries
  • Trauma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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