Experimental models of hepatitis B and C — new insights and progress

Emmanuel Thomas, T. Jake Liang

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Viral hepatitis is a major cause of morbidity and mortality, affecting hundreds of millions of people worldwide. Hepatitis-causing viruses initiate disease by establishing both acute and chronic infections, and several of these viruses are specifically associated with the development of hepatocellular carcinoma. Consequently, intense research efforts have been focusing on increasing our understanding of hepatitis virus biology and on improving antiviral therapy and vaccination strategies. Although valuable information on viral hepatitis emerged from careful epidemiological studies on sporadic outbreaks in humans, experimental models using cell culture, rodent and non-human primates were essential in advancing the field. Through the use of these experimental models, improvement in both the treatment and prevention of viral hepatitis has progressed rapidly; however, agents of viral hepatitis are still among the most common pathogens infecting humans. In this Review, we describe the important part that these experimental models have played in the study of viral hepatitis and led to monumental advances in our understanding and treatment of these pathogens. Ongoing developments in experimental models are also described.

Original languageEnglish (US)
JournalNature Reviews Gastroenterology and Hepatology
DOIs
StateAccepted/In press - Apr 14 2016

Fingerprint

Hepatitis C
Hepatitis B
Hepatitis
Theoretical Models
Hepatitis Viruses
Virus Diseases
Primates
Antiviral Agents
Disease Outbreaks
Epidemiologic Studies
Hepatocellular Carcinoma
Rodentia
Vaccination
Therapeutics
Cell Culture Techniques
Morbidity
Mortality
Research

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Experimental models of hepatitis B and C — new insights and progress. / Thomas, Emmanuel; Liang, T. Jake.

In: Nature Reviews Gastroenterology and Hepatology, 14.04.2016.

Research output: Contribution to journalArticle

@article{c893f19a6ea54dfaba2dc84127d47d24,
title = "Experimental models of hepatitis B and C — new insights and progress",
abstract = "Viral hepatitis is a major cause of morbidity and mortality, affecting hundreds of millions of people worldwide. Hepatitis-causing viruses initiate disease by establishing both acute and chronic infections, and several of these viruses are specifically associated with the development of hepatocellular carcinoma. Consequently, intense research efforts have been focusing on increasing our understanding of hepatitis virus biology and on improving antiviral therapy and vaccination strategies. Although valuable information on viral hepatitis emerged from careful epidemiological studies on sporadic outbreaks in humans, experimental models using cell culture, rodent and non-human primates were essential in advancing the field. Through the use of these experimental models, improvement in both the treatment and prevention of viral hepatitis has progressed rapidly; however, agents of viral hepatitis are still among the most common pathogens infecting humans. In this Review, we describe the important part that these experimental models have played in the study of viral hepatitis and led to monumental advances in our understanding and treatment of these pathogens. Ongoing developments in experimental models are also described.",
author = "Emmanuel Thomas and Liang, {T. Jake}",
year = "2016",
month = "4",
day = "14",
doi = "10.1038/nrgastro.2016.37",
language = "English (US)",
journal = "Nature Reviews Gastroenterology and Hepatology",
issn = "1759-5045",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Experimental models of hepatitis B and C — new insights and progress

AU - Thomas, Emmanuel

AU - Liang, T. Jake

PY - 2016/4/14

Y1 - 2016/4/14

N2 - Viral hepatitis is a major cause of morbidity and mortality, affecting hundreds of millions of people worldwide. Hepatitis-causing viruses initiate disease by establishing both acute and chronic infections, and several of these viruses are specifically associated with the development of hepatocellular carcinoma. Consequently, intense research efforts have been focusing on increasing our understanding of hepatitis virus biology and on improving antiviral therapy and vaccination strategies. Although valuable information on viral hepatitis emerged from careful epidemiological studies on sporadic outbreaks in humans, experimental models using cell culture, rodent and non-human primates were essential in advancing the field. Through the use of these experimental models, improvement in both the treatment and prevention of viral hepatitis has progressed rapidly; however, agents of viral hepatitis are still among the most common pathogens infecting humans. In this Review, we describe the important part that these experimental models have played in the study of viral hepatitis and led to monumental advances in our understanding and treatment of these pathogens. Ongoing developments in experimental models are also described.

AB - Viral hepatitis is a major cause of morbidity and mortality, affecting hundreds of millions of people worldwide. Hepatitis-causing viruses initiate disease by establishing both acute and chronic infections, and several of these viruses are specifically associated with the development of hepatocellular carcinoma. Consequently, intense research efforts have been focusing on increasing our understanding of hepatitis virus biology and on improving antiviral therapy and vaccination strategies. Although valuable information on viral hepatitis emerged from careful epidemiological studies on sporadic outbreaks in humans, experimental models using cell culture, rodent and non-human primates were essential in advancing the field. Through the use of these experimental models, improvement in both the treatment and prevention of viral hepatitis has progressed rapidly; however, agents of viral hepatitis are still among the most common pathogens infecting humans. In this Review, we describe the important part that these experimental models have played in the study of viral hepatitis and led to monumental advances in our understanding and treatment of these pathogens. Ongoing developments in experimental models are also described.

UR - http://www.scopus.com/inward/record.url?scp=84963576481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963576481&partnerID=8YFLogxK

U2 - 10.1038/nrgastro.2016.37

DO - 10.1038/nrgastro.2016.37

M3 - Article

C2 - 27075261

AN - SCOPUS:84963576481

JO - Nature Reviews Gastroenterology and Hepatology

JF - Nature Reviews Gastroenterology and Hepatology

SN - 1759-5045

ER -