Experimental laser interstitial thermotherapy in ex-vivo porcine tissue at 940 nm

Nelson Salas, Fabrice Manns, Jean Marie Parel, Peter J. Milne, Manuel Figueroa, David B. Denham, David S. Robinson

Research output: Contribution to journalArticle

Abstract

The purpose of these experiments was to evaluate the temperature and predicted cell kill distribution during LITT of breast tissue phantoms at 940nm and compare with the results of previous experiments at 830 nm and 980 nm. Material and Methods: A Dornier Medilas D Skinpulse 940 nm diode laser system coupled to a Dornier D-6111-T2 fiber (Dornier Surgical Products, Phoenix, AZ) was used to irradiate the porcine tissue three times at approximately 5 W for 10 minutes. Results: The initial rate of temperature increase at 940 nm for locations 5, 10, and 15 mm from the fiber axis ranged from 0.076 to 0.142 °C/s, 0.027 to 0.041 °C/s, and 0.008 to 0.013 °C/s, respectively, while the maximum temperature increase ranged from 37.8 to 46.9 °C, 19.3 to 26.1 °C, 8.6 to 13.0 °C, respectively. Temperature curves had lower slopes at 940 nm than at 830 nm and 980 nm. The maximum temperature increase was higher at 940 nm than at 830 nm. Predicted area of 100% cell kill was approximately 2 cm by 2 cm. Conclusion: Results of experiments at 940 nm were more comparable to those at 980 nm than at 830 nm.

Original languageEnglish (US)
Pages (from-to)398-403
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4609
Issue number1
DOIs
StatePublished - Jun 14 2002

    Fingerprint

Keywords

  • Breast
  • Diffusing tip
  • Fiber
  • Laser
  • Thermotherapy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this