Abstract
Rabbits received intravitreal injections of gentamicin and indirect ophthalmoscopy, electroretinography, and histopathology determined relative toxicity. An intravitreal dose of 0.1 to 0.2 mg of commercially available gentamicin was well tolerated in the rabbit eye. A dosage of 0.4 mg or higher consistently produced significant ocular toxicity as evidenced by extinction of the electroretinogram, gross fundus changes, and histopathologic alterations.
Original language | English (US) |
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Pages (from-to) | 604-611 |
Number of pages | 8 |
Journal | American journal of ophthalmology |
Volume | 82 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1976 |
ASJC Scopus subject areas
- Ophthalmology