Experimental intravitreal gentamicin

Ihor G. Zachary, Richard K. Forster

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Rabbits received intravitreal injections of gentamicin and indirect ophthalmoscopy, electroretinography, and histopathology determined relative toxicity. An intravitreal dose of 0.1 to 0.2 mg of commercially available gentamicin was well tolerated in the rabbit eye. A dosage of 0.4 mg or higher consistently produced significant ocular toxicity as evidenced by extinction of the electroretinogram, gross fundus changes, and histopathologic alterations.

Original languageEnglish (US)
Pages (from-to)604-611
Number of pages8
JournalAmerican journal of ophthalmology
Volume82
Issue number4
DOIs
StatePublished - Oct 1976

ASJC Scopus subject areas

  • Ophthalmology

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