Experimental intravitreal gentamicin

Ihor G. Zachary; Richard K. Forster

doi:10.1016/0002-9394(76)90549-3

Experimental intravitreal gentamicin

Ihor G. Zachary, Richard K. Forster

Ophthalmology

Research output: Contribution to journal › Article

48 Scopus citations

Abstract

Rabbits received intravitreal injections of gentamicin and indirect ophthalmoscopy, electroretinography, and histopathology determined relative toxicity. An intravitreal dose of 0.1 to 0.2 mg of commercially available gentamicin was well tolerated in the rabbit eye. A dosage of 0.4 mg or higher consistently produced significant ocular toxicity as evidenced by extinction of the electroretinogram, gross fundus changes, and histopathologic alterations.

Original language	English (US)
Pages (from-to)	604-611
Number of pages	8
Journal	American journal of ophthalmology
Volume	82
Issue number	4
DOIs	https://doi.org/10.1016/0002-9394(76)90549-3
State	Published - Oct 1976

ASJC Scopus subject areas

Ophthalmology

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Zachary, I. G., & Forster, R. K. (1976). Experimental intravitreal gentamicin. American journal of ophthalmology, 82(4), 604-611. https://doi.org/10.1016/0002-9394(76)90549-3

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