Experimental intravitreal gentamicin

Ihor G. Zachary; Richard K. Forster

doi:10.1016/0002-9394(76)90549-3

Experimental intravitreal gentamicin

Ihor G. Zachary, Richard K. Forster

Ophthalmology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Rabbits received intravitreal injections of gentamicin and indirect ophthalmoscopy, electroretinography, and histopathology determined relative toxicity. An intravitreal dose of 0.1 to 0.2 mg of commercially available gentamicin was well tolerated in the rabbit eye. A dosage of 0.4 mg or higher consistently produced significant ocular toxicity as evidenced by extinction of the electroretinogram, gross fundus changes, and histopathologic alterations.

Original language	English (US)
Pages (from-to)	604-611
Number of pages	8
Journal	American journal of ophthalmology
Volume	82
Issue number	4
DOIs	https://doi.org/10.1016/0002-9394(76)90549-3
State	Published - Oct 1976

ASJC Scopus subject areas

Ophthalmology

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title = "Experimental intravitreal gentamicin",

abstract = "Rabbits received intravitreal injections of gentamicin and indirect ophthalmoscopy, electroretinography, and histopathology determined relative toxicity. An intravitreal dose of 0.1 to 0.2 mg of commercially available gentamicin was well tolerated in the rabbit eye. A dosage of 0.4 mg or higher consistently produced significant ocular toxicity as evidenced by extinction of the electroretinogram, gross fundus changes, and histopathologic alterations.",

author = "Zachary, {Ihor G.} and Forster, {Richard K.}",

note = "Funding Information: From the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida. This study was supported in part by Public Health Service training grant EY-00028 from the National Eye Institute; the Flournory and Mae Knight Clark Research Fund; the Florida Lions Eye Bank; and the Seeing Eye Foundation.",

year = "1976",

month = oct,

doi = "10.1016/0002-9394(76)90549-3",

language = "English (US)",

volume = "82",

pages = "604--611",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

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T1 - Experimental intravitreal gentamicin

AU - Zachary, Ihor G.

AU - Forster, Richard K.

N1 - Funding Information: From the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida. This study was supported in part by Public Health Service training grant EY-00028 from the National Eye Institute; the Flournory and Mae Knight Clark Research Fund; the Florida Lions Eye Bank; and the Seeing Eye Foundation.

PY - 1976/10

Y1 - 1976/10

N2 - Rabbits received intravitreal injections of gentamicin and indirect ophthalmoscopy, electroretinography, and histopathology determined relative toxicity. An intravitreal dose of 0.1 to 0.2 mg of commercially available gentamicin was well tolerated in the rabbit eye. A dosage of 0.4 mg or higher consistently produced significant ocular toxicity as evidenced by extinction of the electroretinogram, gross fundus changes, and histopathologic alterations.

AB - Rabbits received intravitreal injections of gentamicin and indirect ophthalmoscopy, electroretinography, and histopathology determined relative toxicity. An intravitreal dose of 0.1 to 0.2 mg of commercially available gentamicin was well tolerated in the rabbit eye. A dosage of 0.4 mg or higher consistently produced significant ocular toxicity as evidenced by extinction of the electroretinogram, gross fundus changes, and histopathologic alterations.

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Experimental intravitreal gentamicin

Abstract

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