Experimental increase in brain HIPDM uptake by hypercapnia

N. D. Karatzas, George N Sfakianakis, D. Pappas, Robert C. Duncan, A. Heal, A. Serafini, H. F. Kung

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The 30-min brain uptake of [125I]HIPDM was measured in conscious rats - normocapnic (n = 8), hypercapnic (n = 12), and hyperoxic (n = 6). A mean 41.2% higher uptake was found in the brains of hypercapnic animals (p < 0.01). In the three groups of rats, brain HIPDM uptake had a negative correlation with body weight (p < 0.001) and a positive correlation with arterial pCO2 (p < 0.01), when adjusted for body weight. These results indicate that HIPDM uptake with hypercapnia may be used as a provocative test to measure cerebral blood flow reserves.

Original languageEnglish (US)
Pages (from-to)1675-1682
Number of pages8
JournalJournal of Nuclear Medicine
Issue number10
StatePublished - 1988

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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