Experimental increase in brain HIPDM uptake by hypercapnia

N. D. Karatzas, G. N. Sfakianakis, D. Pappas, R. Duncan, A. Heal, A. Serafini, H. F. Kung

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Abstract

The 30-min brain uptake of [125I]HIPDM was measured in conscious rats - normocapnic (n = 8), hypercapnic (n = 12), and hyperoxic (n = 6). A mean 41.2% higher uptake was found in the brains of hypercapnic animals (p < 0.01). In the three groups of rats, brain HIPDM uptake had a negative correlation with body weight (p < 0.001) and a positive correlation with arterial pCO2 (p < 0.01), when adjusted for body weight. These results indicate that HIPDM uptake with hypercapnia may be used as a provocative test to measure cerebral blood flow reserves.

Original languageEnglish (US)
Pages (from-to)1675-1682
Number of pages8
JournalJournal of Nuclear Medicine
Volume29
Issue number10
StatePublished - Jan 1 1988

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Karatzas, N. D., Sfakianakis, G. N., Pappas, D., Duncan, R., Heal, A., Serafini, A., & Kung, H. F. (1988). Experimental increase in brain HIPDM uptake by hypercapnia. Journal of Nuclear Medicine, 29(10), 1675-1682.