The 30-min brain uptake of [125I]HIPDM was measured in conscious rats - normocapnic (n = 8), hypercapnic (n = 12), and hyperoxic (n = 6). A mean 41.2% higher uptake was found in the brains of hypercapnic animals (p < 0.01). In the three groups of rats, brain HIPDM uptake had a negative correlation with body weight (p < 0.001) and a positive correlation with arterial pCO2 (p < 0.01), when adjusted for body weight. These results indicate that HIPDM uptake with hypercapnia may be used as a provocative test to measure cerebral blood flow reserves.
|Original language||English (US)|
|Number of pages||8|
|Journal||Journal of Nuclear Medicine|
|State||Published - 1988|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging