Experimental embolic stroke in the guinea pig (cuvis cobaya)

Daniel Heffez, William Sheremata

Research output: Contribution to journalArticlepeer-review


Because of the demonstrated suitability of the guinea pig (Cuvis cobaya) for a large variety of laboratory investigations, the authors sought to develop a stroke model in this animal. Many ingenious stroke models in other animals exist; some depend on anomalous anatomy, others utilize methods of intracranial or extracranial vascular occlusion and yet others combine ischemia and anoxic damage. As one proposed application for this work was to study immune responses following experimental stroke, survival of several days after cerebral infarction was a requirement. Three to five days elapse before detection of a humoral and cellular immune response is possible. The guinea pig is especially suited to immunological studies because of the enormous amount of accumulated data on the immunology of this animal. However, the guinea pig has proved relatively invulnerable to existing small animal techniques. Moreover, the unacceptably short postoperative survival associated with the use of existing techniques necessitated the development of a new procedure. The authors have successfully pursued the development of an embolic stroke procedure applicable to this animal.

Original languageEnglish (US)
Pages (from-to)82-87
Number of pages6
JournalJournal of neuropathology and experimental neurology
Issue number1
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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