Experimental Diet-Induced Atherosclerosis in Quaker Parrots (Myiopsitta monachus)

H. Beaufrère, J. G. Nevarez, N. Wakamatsu, S. Clubb, Carolyn Cray, T. N. Tully

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Spontaneous atherosclerosis is common in psittaciformes, and clinical signs associated with flow-limiting stenosis are encountered in pet birds. Nevertheless, a psittacine model of atherosclerosis has not been developed for research investigations. Sixteen captive-bred Quaker parrots (Myiopsitta monachus) were used in this study. While 4 control birds were fed a maintenance diet, 12 other birds were fed an atherogenic diet composed of 1% cholesterol controlling for a calorie-to-protein ratio for periods ranging from 2 to 8 months. The birds were euthanized at the end of their respective food trial period. Histopathology, transmission electron microscopy, and cholesterol measurement were performed on the ascending aorta and brachiocephalic and pulmonary arteries. Plasma lipoproteins, cholesterol, and triglycerides were also measured on a monthly basis. Significant atherosclerotic lesions were induced within 2 months and advanced atherosclerotic lesions within 4 to 6 months. The advanced lesions were histologically similar to naturally occurring lesions identified in the same parrot species with a lipid core and a fibrous cap. Ultrastructurally, there were extracellular lipid, foam cell, and endothelial changes. Arterial cholesterol content increased linearly over time. Plasma cholesterol and low-density lipoprotein (LDL) significantly increased over time by an average of 5- and 15-fold, respectively, with a shift from high-density lipoprotein to LDL as the main plasma lipoprotein. Quaker parrots also exhibited high plasma cholesteryl ester transfer protein activity that increased, although not significantly, over time. This experiment demonstrates that in Quaker parrots fed 1% cholesterol, advanced atherosclerosis can be induced relatively quickly, and lesions resemble those found in other avian models and humans.

Original languageEnglish
Pages (from-to)1116-1126
Number of pages11
JournalVeterinary Pathology
Volume50
Issue number6
DOIs
StatePublished - Nov 1 2013

Fingerprint

Parrots
Monachus
parrots
atherosclerosis
experimental diets
Birds
Atherosclerosis
lesions (animal)
Psittaciformes
Cholesterol
cholesterol
Diet
Period Circadian Proteins
low density lipoprotein
Atherogenic Diet
Cholesterol Ester Transfer Proteins
Lipids
lipoproteins
Foam Cells
birds

Keywords

  • animal model of atherosclerosis
  • avian atherosclerosis
  • avian cardiology
  • psittacine atherosclerosis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Beaufrère, H., Nevarez, J. G., Wakamatsu, N., Clubb, S., Cray, C., & Tully, T. N. (2013). Experimental Diet-Induced Atherosclerosis in Quaker Parrots (Myiopsitta monachus). Veterinary Pathology, 50(6), 1116-1126. https://doi.org/10.1177/0300985813488958

Experimental Diet-Induced Atherosclerosis in Quaker Parrots (Myiopsitta monachus). / Beaufrère, H.; Nevarez, J. G.; Wakamatsu, N.; Clubb, S.; Cray, Carolyn; Tully, T. N.

In: Veterinary Pathology, Vol. 50, No. 6, 01.11.2013, p. 1116-1126.

Research output: Contribution to journalArticle

Beaufrère, H, Nevarez, JG, Wakamatsu, N, Clubb, S, Cray, C & Tully, TN 2013, 'Experimental Diet-Induced Atherosclerosis in Quaker Parrots (Myiopsitta monachus)', Veterinary Pathology, vol. 50, no. 6, pp. 1116-1126. https://doi.org/10.1177/0300985813488958
Beaufrère, H. ; Nevarez, J. G. ; Wakamatsu, N. ; Clubb, S. ; Cray, Carolyn ; Tully, T. N. / Experimental Diet-Induced Atherosclerosis in Quaker Parrots (Myiopsitta monachus). In: Veterinary Pathology. 2013 ; Vol. 50, No. 6. pp. 1116-1126.
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