Experimental deprivation of choroidal blood flow. Retinal morphology, early receptor potential, and electroretinography

Helmut Buettner, Robert Machemer, Steve Charles, Douglas Anderson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Experimental deprivation of the choroidal blood flow up to 24 hours in owl monkey eyes resulted in final necrosis of the pigment epithelium and photoreceptor cells. Müller cells did not show morphologic deterioration. The inner retinal layers exhibited marked extracellular edema, but no intracellular or vascular damage. The electroretinogram's B-wave disappeared early, followed by the disappearance of the A-wave, but the early receptor potential remained intact for 12 hours. The electrophysiologic changes correlate well with the sequence of morphological changes. These findings show that retinal pigment epithelium and photoreceptors depend mostly on supply from the choridal circulation. The extracellular edema of the inner retinal layers if evidence for a mechanism by which fluid is normally removed from the retina into the choroid via the retinal pigment epithelium.

Original languageEnglish
Pages (from-to)943-952
Number of pages10
JournalAmerican Journal of Ophthalmology
Volume75
Issue number6
StatePublished - Jan 1 1973

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Electroretinography
Retinal Pigment Epithelium
Aotidae
Photoreceptor Cells
Papilledema
Vertebrate Photoreceptor Cells
Choroid
Blood Vessels
Retina
Edema
Necrosis
Epithelium

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Experimental deprivation of choroidal blood flow. Retinal morphology, early receptor potential, and electroretinography. / Buettner, Helmut; Machemer, Robert; Charles, Steve; Anderson, Douglas.

In: American Journal of Ophthalmology, Vol. 75, No. 6, 01.01.1973, p. 943-952.

Research output: Contribution to journalArticle

Buettner, Helmut ; Machemer, Robert ; Charles, Steve ; Anderson, Douglas. / Experimental deprivation of choroidal blood flow. Retinal morphology, early receptor potential, and electroretinography. In: American Journal of Ophthalmology. 1973 ; Vol. 75, No. 6. pp. 943-952.
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