Experimental combination chemotherapy: Intracarotid versus intravenous administration of aziridinylbenzoquinone, BCNU, and cisplatin in dogs

K. C. Wright, L. C. Stephens, S. Wallace, Niramol Savaraj, Lynn G Feun

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Sixteen adult beagles (10-12 kg) were used to evaluate combinations of 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone (AZQ, aziridinylbenzoquinone), 1,3-bis-2-chloroethyl-1-nitrosourea (BCNU, carmustine), and cis-dichlorodiammineplatinum(II) (CDDP, cisplatin) administered by intravenous or intracarotid infusion. Moderate to severe systemic toxicities resulted from all drug infusions, but no histopathologic changes were found in the central nervous system (CNS) of any of the dogs. Results indicated that the toxicities were not dependent on the route of administration or the recipient's gender, and they were reversible in most cases with intravenous supportive therapy. Cisplatin seemed to have an additive effect when administered in combination with AZQ and/or BCNU.

Original languageEnglish
Pages (from-to)437-444
Number of pages8
JournalChemotherapy
Volume33
Issue number6
StatePublished - Dec 1 1987
Externally publishedYes

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Carmustine
Combination Drug Therapy
Intravenous Administration
Cisplatin
Dogs
Central Nervous System
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)

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Experimental combination chemotherapy : Intracarotid versus intravenous administration of aziridinylbenzoquinone, BCNU, and cisplatin in dogs. / Wright, K. C.; Stephens, L. C.; Wallace, S.; Savaraj, Niramol; Feun, Lynn G.

In: Chemotherapy, Vol. 33, No. 6, 01.12.1987, p. 437-444.

Research output: Contribution to journalArticle

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