Experimental cerebral malaria develops independently of endothelial expression of intercellular adhesion molecule-1 (ICAM-1)

Theresa N. Ramos, Daniel C. Bullard, Meghan M. Darley, Kristin McDonald, David F. Crawford, Scott R. Barnum

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Endothelium-expressed intercellular adhesion molecule-1 (ICAM-1) is considered critical for the development of cerebral malaria (CM). Results: ICAM-1 expression on leukocytes alone was sufficient for the development of experimental CM. Conclusion: Endothelial expression of ICAM-1 is not required for development of CM. Significance: Vascular occlusion inCMrequires ICAM-1 expression on leukocytes but not endothelial cells.

Original languageEnglish (US)
Pages (from-to)10962-10966
Number of pages5
JournalJournal of Biological Chemistry
Volume288
Issue number16
DOIs
StatePublished - Apr 19 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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