Experience with islet immunoalteration in dogs: In vitro and in vivo studies

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

In an attempt to prolong canine islet allograft survival, in the presence of minimal or no recipient immunosuppression' two methods of islet immunoalteration were utilized prior to transplantation. With or without administration of subimmunosuppressive doses of cyclosporin A (CSA) to recipients, treatment of islets with anti-class II monoclonal antibody (moab) and complement (C) resulted in prolongation of allograft survival when treatment was combined with a culture period of 7 days. Transplantation of ultraviolet light (UV) irradiated, 24 hour cultured islets into recipients of subimmunosuppressive doses of CSA also resulted in modest prolongation of allograft survival.

Original languageEnglish (US)
Pages (from-to)119-122
Number of pages4
JournalHormone and Metabolic Research
Volume25
Issue numberSUPPL.
StatePublished - Dec 1 1990

    Fingerprint

Keywords

  • anti-class II
  • immunoalteration
  • islet transplantation
  • ultraviolet light

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this