Experience with an Automated Microwave-Assisted Rapid Tissue Processing Method: Validation of Histologic Quality and Impact on the Timeliness of Diagnostic Surgical Pathology

Azorides R. Morales, Mehdi Nassiri, Rima Kanhoush, Vladimir Vincek, Mehrdad Nadji

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

We studied the effect of a fully automated microwave-assisted rapid tissue processor (RTP) on histologic examination and on the turnaround time for surgical pathology reports. A quality assurance program reviewed the histologic sections obtained by the rapid processing method for the last 3 calendar years. In addition, the histologic results from this method were compared blindly with those obtained from the conventional overnight tissue processing (CTP) method by 9 pathologists with different levels of experience. The surgical pathology turnaround times for 1 year of use of the RTP were compared with the last year for CTP. We found that the RTP reproducibly yielded histologic material comparable in quality to CTP. The turnaround time for surgical pathology reports was improved substantially, and, in particular, same-day reporting was achieved in approximately 55% of cases compared with fewer than 1% before use of the RTP. Moreover, use of the RTP enhanced safety by eliminating formalin and xylene from the procedure.

Original languageEnglish (US)
Pages (from-to)528-536
Number of pages9
JournalAmerican journal of clinical pathology
Volume121
Issue number4
DOIs
StatePublished - Apr 2004

Keywords

  • Histology
  • Microwave
  • Surgical pathology
  • Tissue processing

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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