Experience with Althesin in the management of persistently raised ICP following severe head injury

R. Bullock, J. R. van Dellen, D. Campbell, I. Osborn, S. G. Reinach

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Of 243 patients who underwent intracranial pressure (ICP) monitoring after severe head injury, 42 (17%) were found to have severe persistently raised ICP, in spite of hyperventilation, mannitol, and surgical decompression. Althesin was infused to reduce ICP in these patients. This agent was shown to be effective and safe in reducing ICP, and a significant improvement in cerebral perfusion pressure was demonstrated. In this respect, Althesin may be more effective than barbiturates. However, no improvement in patient outcome was demonstrated in this series.

Original languageEnglish (US)
Pages (from-to)414-419
Number of pages6
JournalJournal of neurosurgery
Volume64
Issue number3
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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