Experience with aggressive therapy in three children with unresectable malignant liver tumors

N. A. Dower, Lesley J Smith, G. Lees, N. Kneteman, H. Idikio, J. Emond, P. Rosenthal

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background. Children with malignant liver tumors often present with unresectable disease but need not be considered incurable. The advent of effective chemotherapy makes aggressive management feasible, as our experience with three such patients demonstrates. Procedure and Results. One child with an unresectable undifferentiated sarcoma of the liver and two others with unresectable primary hepatoblastoma and lung metastases were treated with initial chemotherapy, followed by aggressive surgical management. Treatment with chemotherapy followed by hepatectomy and liver transplantation (cadaveric or live donor) in two children has resulted in disease-free survivals of 79 and 38 months. The third patient is alive and well 24 months following chemotherapy and aggressive resection of the primary and 12 metastatic lesions. Conclusions. Initial chemotherapy for unresectable liver tumors with or without metastases is supported by the review of the literature. Consideration of orthotopic liver transplantation (OLT) from cadaveric or living related donor is warranted when the malignancy is demonstrably chemosensitive, independent of initial staging. Aggressive resection of primary and metastatic disease may be called for in selected cases. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)132-135
Number of pages4
JournalMedical and Pediatric Oncology
Volume34
Issue number2
DOIs
StatePublished - Feb 1 2000
Externally publishedYes

Fingerprint

Drug Therapy
Liver
Neoplasms
Liver Transplantation
Neoplasm Metastasis
Hepatoblastoma
Therapeutics
Living Donors
Hepatectomy
Sarcoma
Disease-Free Survival
Tissue Donors
Lung

Keywords

  • Childhood cancer
  • Hepatoblastoma
  • Orthotopic liver transplantation
  • Unresectable hepatic malignant tumors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this

Experience with aggressive therapy in three children with unresectable malignant liver tumors. / Dower, N. A.; Smith, Lesley J; Lees, G.; Kneteman, N.; Idikio, H.; Emond, J.; Rosenthal, P.

In: Medical and Pediatric Oncology, Vol. 34, No. 2, 01.02.2000, p. 132-135.

Research output: Contribution to journalArticle

Dower, N. A. ; Smith, Lesley J ; Lees, G. ; Kneteman, N. ; Idikio, H. ; Emond, J. ; Rosenthal, P. / Experience with aggressive therapy in three children with unresectable malignant liver tumors. In: Medical and Pediatric Oncology. 2000 ; Vol. 34, No. 2. pp. 132-135.
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