Abstract
A number of putative β-turn mimetics that incorporate sidechain functionality at the i + 1, i + 2, and i + 3 positions were synthesized on solid support in high levels of purity and in good overall yields from readily available starting materials. A variety of sidechain functionality, ring sizes, and sidechain stereochemistries were introduced demonstrating the generality of the synthesis method. A significant feature of the synthesis sequence is the use of guanidine resin that functions as both a solid-phase extraction resin and a support-bound general base catalyst.
| Original language | English |
|---|---|
| Pages (from-to) | 6961-6964 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 37 |
| Issue number | 39 |
| DOIs | |
| State | Published - Sep 23 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Expedient solid-phase synthesis of putative β-turn mimetics incorporating the i + 1, i + 2, and i + 3 sidechains. / Virgilio, Alex A.; Schuerer, Stephan C; Ellman, Jonathan A.
In: Tetrahedron Letters, Vol. 37, No. 39, 23.09.1996, p. 6961-6964.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expedient solid-phase synthesis of putative β-turn mimetics incorporating the i + 1, i + 2, and i + 3 sidechains
AU - Virgilio, Alex A.
AU - Schuerer, Stephan C
AU - Ellman, Jonathan A.
PY - 1996/9/23
Y1 - 1996/9/23
N2 - A number of putative β-turn mimetics that incorporate sidechain functionality at the i + 1, i + 2, and i + 3 positions were synthesized on solid support in high levels of purity and in good overall yields from readily available starting materials. A variety of sidechain functionality, ring sizes, and sidechain stereochemistries were introduced demonstrating the generality of the synthesis method. A significant feature of the synthesis sequence is the use of guanidine resin that functions as both a solid-phase extraction resin and a support-bound general base catalyst.
AB - A number of putative β-turn mimetics that incorporate sidechain functionality at the i + 1, i + 2, and i + 3 positions were synthesized on solid support in high levels of purity and in good overall yields from readily available starting materials. A variety of sidechain functionality, ring sizes, and sidechain stereochemistries were introduced demonstrating the generality of the synthesis method. A significant feature of the synthesis sequence is the use of guanidine resin that functions as both a solid-phase extraction resin and a support-bound general base catalyst.
UR - http://www.scopus.com/inward/record.url?scp=0030599243&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030599243&partnerID=8YFLogxK
U2 - 10.1016/0040-4039(96)01572-9
DO - 10.1016/0040-4039(96)01572-9
M3 - Article
AN - SCOPUS:0030599243
VL - 37
SP - 6961
EP - 6964
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 39
ER -