Abstract
A number of putative β-turn mimetics that incorporate sidechain functionality at the i + 1, i + 2, and i + 3 positions were synthesized on solid support in high levels of purity and in good overall yields from readily available starting materials. A variety of sidechain functionality, ring sizes, and sidechain stereochemistries were introduced demonstrating the generality of the synthesis method. A significant feature of the synthesis sequence is the use of guanidine resin that functions as both a solid-phase extraction resin and a support-bound general base catalyst.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6961-6964 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 37 |
| Issue number | 39 |
| DOIs | |
| State | Published - Sep 23 1996 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Virgilio, A. A., Schürer, S. C., & Ellman, J. A. (1996). Expedient solid-phase synthesis of putative β-turn mimetics incorporating the i + 1, i + 2, and i + 3 sidechains. Tetrahedron Letters, 37(39), 6961-6964. https://doi.org/10.1016/0040-4039(96)01572-9