Abstract
A number of putative β-turn mimetics that incorporate sidechain functionality at the i + 1, i + 2, and i + 3 positions were synthesized on solid support in high levels of purity and in good overall yields from readily available starting materials. A variety of sidechain functionality, ring sizes, and sidechain stereochemistries were introduced demonstrating the generality of the synthesis method. A significant feature of the synthesis sequence is the use of guanidine resin that functions as both a solid-phase extraction resin and a support-bound general base catalyst.
Original language | English (US) |
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Pages (from-to) | 6961-6964 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 37 |
Issue number | 39 |
DOIs | |
State | Published - Sep 23 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry