Expanded Fluorocarbon for Keratoprosthesis Cellular Ingrowth and Transparency

Jean Marc Legeais, Gilles Renard, Jean Marie Parel, Olivia Serdarevic, Mei Mei-Mui, Yves Pouliquen

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

The development of a synthetic material allowing increased cellular adhesion and ingrowth would improve keratoprosthetic devices and requires an understanding of cell colonization processes. Interlamellar implantation of hydrophobic synthetic material may lead to poor corneal nutrition with subsequent necrosis. The probability of necrosis increases with material which is more impermeable, larger in diameter and more anterior in its placement. In this study we demonstrated the importance of pore diameter in the rate and density of cell colonization. We demonstrated that an opaque hydrophobic material may become translucent and wettable with very low perturbation of flow through the cornea. We used an expanded polytetrafluoroethylene with either 20 μm or 50 μm pore diameter. Cellular ingrowth was significantly greater in the material with 50 μm pores, resulting in collagen deposition within the pores without corneal vascularization at 6 months follow-up. Immunohistochemical study with monoclonal antibody AE5 revealed normal epithelial differentiation on the surface of the cornea over the implanted polymer.

Original languageEnglish (US)
Pages (from-to)41-51
Number of pages11
JournalExperimental Eye Research
Volume58
Issue number1
DOIs
StatePublished - Jan 1994

Keywords

  • artificial cornea
  • cornea
  • keratoprosthesis
  • polytetrafluoroethylene
  • transparency

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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