Exosomes and Exosomal miRNA in Respiratory Diseases

Shamila D. Alipoor, Esmaeil Mortaz, Johan Garssen, Masoud Movassaghi, Mehdi Mirsaeidi, Ian M. Adcock

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly miRNAs, to both neighboring and distal cells, they are considered important in cell-cell communication. Recent evidence has shown their possible importance in the pathogenesis of several pulmonary diseases. The differential expression of exosomes and of exosomal miRNAs in disease has driven their promise as biomarkers of disease enabling noninvasive clinical diagnosis in addition to their use as therapeutic tools. In this review, we summarize recent advances in this area as applicable to pulmonary diseases.

Original languageEnglish (US)
Article number5628404
JournalMediators of Inflammation
Volume2016
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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    Alipoor, S. D., Mortaz, E., Garssen, J., Movassaghi, M., Mirsaeidi, M., & Adcock, I. M. (2016). Exosomes and Exosomal miRNA in Respiratory Diseases. Mediators of Inflammation, 2016, [5628404]. https://doi.org/10.1155/2016/5628404