@article{586ea0f8d44a424f8521d5e38a9b0502,
title = "Exon-intron organization, expression, and chromosomal localization of the human motilin gene",
abstract = "The human motilin gene has been isolated and characterized. The gene spans about 9 kilobase pairs (kb) and the 0.7 kb motilin mRNA is encoded by five exons. The 22-amino-acid motilin sequence is encoded by exons 2 and 3. The human motilin gene was mapped to the p21.2→p21.3 region of chromosome 6 by hybridization of the cloned cDNA to DNAs from a panel of reduced human-mouse somatic cell hybrids and by in situ hybridization to human prometaphase chromosomes. RNA blotting using RNA prepared from various regions of the human gastrointestinal tract revealed high levels of motilin mRNA in duodenum and lower levels in the antrum of the stomach; motilin mRNA could not be detected by this procedure in the esophagus, cardia of the stomach, descending colon or gallbladder.",
keywords = "(Duodenum, Stomach, Human), Chromosome 6, Motilin gene",
author = "H. Yano and Y. Seino and J. Fujita and Y. Yamada and N. Inagaki and J. Takeda and Bell, {G. I.} and Eddy, {R. L.} and Fan, {Y. S.} and Byers, {M. G.} and Shows, {T. B.} and H. Imura",
note = "Funding Information: Acknowledgements: We are very grateful to Dr S. Ishii (Riken), Dr H. Fukumoto and Dr G. Koh (Kyoto University) for valuable advice in these studies. We also express our appreciation to T. Mitani (Sanwa Kagaku Kenkyusho) for preparation of the synthetic oligonucleotide used for primer extension analysis, and to Ms H. Tachikawa for her expert assistance in preparing this manuscript. This research was supported by Grants in Aid for Scientific Research 63440042 from the Ministry of Education, Science, and Culture, Japan (to H.I.), in part by Uehara Memorial Foundation and Grant-in-Aid from the Mochida Memorial Foundation for Medical and Pharmaceutical Research (to Y.S.), and by National Institutes of Health Grants GM-2054 and HD-05196 (to T.B.S.).",
year = "1989",
month = jun,
day = "5",
doi = "10.1016/0014-5793(89)80633-7",
language = "English (US)",
volume = "249",
pages = "248--252",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "2",
}