Exon-intron organization, expression, and chromosomal localization of the human motilin gene

H. Yano; Y. Seino; J. Fujita; Y. Yamada; N. Inagaki; J. Takeda; G. I. Bell; R. L. Eddy; Y. S. Fan; M. G. Byers; T. B. Shows; H. Imura

doi:10.1016/0014-5793(89)80633-7

Exon-intron organization, expression, and chromosomal localization of the human motilin gene

H. Yano, Y. Seino, J. Fujita, Y. Yamada, N. Inagaki, J. Takeda, G. I. Bell, R. L. Eddy, Y. S. Fan, M. G. Byers, T. B. Shows, H. Imura

Research output: Contribution to journal › Article

16 Scopus citations

Abstract

The human motilin gene has been isolated and characterized. The gene spans about 9 kilobase pairs (kb) and the 0.7 kb motilin mRNA is encoded by five exons. The 22-amino-acid motilin sequence is encoded by exons 2 and 3. The human motilin gene was mapped to the p21.2→p21.3 region of chromosome 6 by hybridization of the cloned cDNA to DNAs from a panel of reduced human-mouse somatic cell hybrids and by in situ hybridization to human prometaphase chromosomes. RNA blotting using RNA prepared from various regions of the human gastrointestinal tract revealed high levels of motilin mRNA in duodenum and lower levels in the antrum of the stomach; motilin mRNA could not be detected by this procedure in the esophagus, cardia of the stomach, descending colon or gallbladder.

Original language	English (US)
Pages (from-to)	248-252
Number of pages	5
Journal	FEBS letters
Volume	249
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(89)80633-7
State	Published - Jun 5 1989
Externally published	Yes

Keywords

(Duodenum, Stomach, Human)
Chromosome 6
Motilin gene

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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Yano, H., Seino, Y., Fujita, J., Yamada, Y., Inagaki, N., Takeda, J., Bell, G. I., Eddy, R. L., Fan, Y. S., Byers, M. G., Shows, T. B., & Imura, H. (1989). Exon-intron organization, expression, and chromosomal localization of the human motilin gene. FEBS letters, 249(2), 248-252. https://doi.org/10.1016/0014-5793(89)80633-7

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title = "Exon-intron organization, expression, and chromosomal localization of the human motilin gene",

abstract = "The human motilin gene has been isolated and characterized. The gene spans about 9 kilobase pairs (kb) and the 0.7 kb motilin mRNA is encoded by five exons. The 22-amino-acid motilin sequence is encoded by exons 2 and 3. The human motilin gene was mapped to the p21.2→p21.3 region of chromosome 6 by hybridization of the cloned cDNA to DNAs from a panel of reduced human-mouse somatic cell hybrids and by in situ hybridization to human prometaphase chromosomes. RNA blotting using RNA prepared from various regions of the human gastrointestinal tract revealed high levels of motilin mRNA in duodenum and lower levels in the antrum of the stomach; motilin mRNA could not be detected by this procedure in the esophagus, cardia of the stomach, descending colon or gallbladder.",

keywords = "(Duodenum, Stomach, Human), Chromosome 6, Motilin gene",

author = "H. Yano and Y. Seino and J. Fujita and Y. Yamada and N. Inagaki and J. Takeda and Bell, {G. I.} and Eddy, {R. L.} and Fan, {Y. S.} and Byers, {M. G.} and Shows, {T. B.} and H. Imura",

year = "1989",

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doi = "10.1016/0014-5793(89)80633-7",

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AU - Yano, H.

AU - Seino, Y.

AU - Fujita, J.

AU - Yamada, Y.

AU - Inagaki, N.

AU - Takeda, J.

AU - Bell, G. I.

AU - Eddy, R. L.

AU - Fan, Y. S.

AU - Byers, M. G.

AU - Shows, T. B.

AU - Imura, H.

PY - 1989/6/5

Y1 - 1989/6/5

N2 - The human motilin gene has been isolated and characterized. The gene spans about 9 kilobase pairs (kb) and the 0.7 kb motilin mRNA is encoded by five exons. The 22-amino-acid motilin sequence is encoded by exons 2 and 3. The human motilin gene was mapped to the p21.2→p21.3 region of chromosome 6 by hybridization of the cloned cDNA to DNAs from a panel of reduced human-mouse somatic cell hybrids and by in situ hybridization to human prometaphase chromosomes. RNA blotting using RNA prepared from various regions of the human gastrointestinal tract revealed high levels of motilin mRNA in duodenum and lower levels in the antrum of the stomach; motilin mRNA could not be detected by this procedure in the esophagus, cardia of the stomach, descending colon or gallbladder.

AB - The human motilin gene has been isolated and characterized. The gene spans about 9 kilobase pairs (kb) and the 0.7 kb motilin mRNA is encoded by five exons. The 22-amino-acid motilin sequence is encoded by exons 2 and 3. The human motilin gene was mapped to the p21.2→p21.3 region of chromosome 6 by hybridization of the cloned cDNA to DNAs from a panel of reduced human-mouse somatic cell hybrids and by in situ hybridization to human prometaphase chromosomes. RNA blotting using RNA prepared from various regions of the human gastrointestinal tract revealed high levels of motilin mRNA in duodenum and lower levels in the antrum of the stomach; motilin mRNA could not be detected by this procedure in the esophagus, cardia of the stomach, descending colon or gallbladder.

KW - (Duodenum, Stomach, Human)

KW - Chromosome 6

KW - Motilin gene

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