Exogenous Fungal Endophthalmitis

Stephen C. Pflugfelder, Harry W. Flynn, Todd A. Zwickey, Richard K. Forster, Aphrodite Tsiligianni, William W. Culbertson, Sid Mandelbaum

Research output: Contribution to journalArticle

160 Scopus citations

Abstract

The authors report 19 cases of exogenous fungal endophthalmitis managed between 1969 and 1986. These developed after ocular surgery (5 cases), after trauma (6 cases), by intraocular spread from fungal keratitis (4 cases), after therapeutic keratoplasty for keratitis (3 cases), and by spontaneous infection of a filtration bleb (1 case). The diagnosis of endophthalmitis was made from 3 days of 4 months after surgery or trauma. In patients with preexisting keratitis, endophthalmitis was noted 2 weeks to 5 months after the onset of keratitis. Seventeen cases were caused by filamentous fungi; two were caused by yeast. Fusarium (6 cases) and Acremonium (3 cases) accounted for approximately one half of the isolates. Forty-two percent of the patients recovered 20/400 or better acuity (3 of 5 postoperative cases, 4 of 6 trauma cases, and 1 of 4 keratitis cases). The clinical and microbiologic features of these cases are presented, and recommendations for management are offered.

Original languageEnglish (US)
Pages (from-to)19-30
Number of pages12
JournalOphthalmology
Volume95
Issue number1
DOIs
StatePublished - Jan 1 1988

Keywords

  • antifungal therapy
  • fungal endophthalmitis
  • fungal keratitis
  • postoperative endophthalmitis
  • traumatic endophthalmitis
  • vitrectomy

ASJC Scopus subject areas

  • Ophthalmology

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    Pflugfelder, S. C., Flynn, H. W., Zwickey, T. A., Forster, R. K., Tsiligianni, A., Culbertson, W. W., & Mandelbaum, S. (1988). Exogenous Fungal Endophthalmitis. Ophthalmology, 95(1), 19-30. https://doi.org/10.1016/S0161-6420(88)33229-X