Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and RB-hSWI/SNF

H. Steven Zhang, Mark Gavin, Anjali Dahiya, Antonio A. Postigo, Duanduan Ma, Robin X. Luo, J. William Harbour, Douglas C. Dean

Research output: Contribution to journalArticle

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Abstract

We present evidence that Rb forms a repressor containing histone deacetylase (HDAC) and the hSWI/SNF nucleosome remodeling complex, which inhibits transcription of genes for cyclins E and A and arrests cells in the G1 phase of the cell cycle. Phosphorylation of Rb by cyclin D/cdk4 disrupts association with HDAC, relieving repression of the cyclin E gene and G1 arrest. However, the Rb-hSWI/SNF complex persists and is sufficient to maintain repression of the cyclin A and cdc2 genes, inhibiting exit from S phase. HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF then appear to maintain the order of cyclin E and A expression during the cell cycle, which in turn regulates exit from G1 and from S phase, respectively.

Original languageEnglish
Pages (from-to)79-89
Number of pages11
JournalCell
Volume101
Issue number1
StatePublished - Mar 31 2000
Externally publishedYes

Fingerprint

Cyclin A
Cyclin E
Histone Deacetylases
G1 Phase
S Phase
Cell Cycle
Genes
Cells
Cyclin G1
Cyclin D
Phosphorylation
Nucleosomes
Transcription
Association reactions

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Zhang, H. S., Gavin, M., Dahiya, A., Postigo, A. A., Ma, D., Luo, R. X., ... Dean, D. C. (2000). Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and RB-hSWI/SNF. Cell, 101(1), 79-89.

Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and RB-hSWI/SNF. / Zhang, H. Steven; Gavin, Mark; Dahiya, Anjali; Postigo, Antonio A.; Ma, Duanduan; Luo, Robin X.; William Harbour, J.; Dean, Douglas C.

In: Cell, Vol. 101, No. 1, 31.03.2000, p. 79-89.

Research output: Contribution to journalArticle

Zhang, HS, Gavin, M, Dahiya, A, Postigo, AA, Ma, D, Luo, RX, William Harbour, J & Dean, DC 2000, 'Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and RB-hSWI/SNF', Cell, vol. 101, no. 1, pp. 79-89.
Zhang HS, Gavin M, Dahiya A, Postigo AA, Ma D, Luo RX et al. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and RB-hSWI/SNF. Cell. 2000 Mar 31;101(1):79-89.
Zhang, H. Steven ; Gavin, Mark ; Dahiya, Anjali ; Postigo, Antonio A. ; Ma, Duanduan ; Luo, Robin X. ; William Harbour, J. ; Dean, Douglas C. / Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and RB-hSWI/SNF. In: Cell. 2000 ; Vol. 101, No. 1. pp. 79-89.
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AB - We present evidence that Rb forms a repressor containing histone deacetylase (HDAC) and the hSWI/SNF nucleosome remodeling complex, which inhibits transcription of genes for cyclins E and A and arrests cells in the G1 phase of the cell cycle. Phosphorylation of Rb by cyclin D/cdk4 disrupts association with HDAC, relieving repression of the cyclin E gene and G1 arrest. However, the Rb-hSWI/SNF complex persists and is sufficient to maintain repression of the cyclin A and cdc2 genes, inhibiting exit from S phase. HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF then appear to maintain the order of cyclin E and A expression during the cell cycle, which in turn regulates exit from G1 and from S phase, respectively.

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