Exercise intolerance in pulmonary hypertension: mechanism, evaluation and clinical implications

Abraham Samuel Babu, Ross Arena, Jonathan Myers, Ramachandran Padmakumar, Arun G. Maiya, Lawrence P Cahalin, Aaron B. Waxman, Carl J. Lavie

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Introduction: Exercise intolerance in pulmonary hypertension (PH) is a major factor affecting activities of daily living and quality of life. Evaluation strategies (i.e., non-invasive and invasive tests) are integral to providing a comprehensive assessment of clinical and functional status. Despite a growing body of literature on the clinical consequences of PH, there are limited studies discussing the contribution of various physiological systems to exercise intolerance in this patient population. Areas covered: This review, through a search of various databases, describes the physiological basis for exercise intolerance across the various PH etiologies, highlights the various exercise evaluation methods and discusses the rationale for exercise training amongst those diagnosed with PH. Expert commentary: With the growing importance of evaluating exercise capacity in PH (class 1, Level C recommendation), understanding why exercise performance is altered in PH is crucial. Thus, the further study is required for better quality evidence in this area.

Original languageEnglish (US)
Pages (from-to)979-990
Number of pages12
JournalExpert Review of Respiratory Medicine
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • cardiopulmonary exercise testing
  • Exercise
  • exercise capacity
  • pulmonary hypertension

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health

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