Executive dysfunction in homebound older people with diabetes mellitus

Wei Qiao Qiu, Lori Lyn Price, Patricia Hibberd, Jennifer Buell, Lauren Collins, Drew Leins, David Mkaya Mwamburi, Irwin Rosenberg, Lauren Smaldone, Tammy M. Scott, Richard D. Siegel, Paul Summergrad, Xiaoyan Sun, Carey Wagner, Lixia Wang, Jacqueline Yee, Katherine L. Tucker, Marshal Folstein

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

OBJECTIVES: To describe patterns of cognitive deficits and activities of daily living (ADLs) in older people with diabetes mellitus. DESIGN: Cross-sectional, population-based study. SETTING: Three homecare agency areas in Boston, Massachusetts. PARTICIPANTS: Two hundred ninety-one homebound people aged 60 and older; 40% with diabetes mellitus. MEASUREMENTS: Demographic data; evidence of diabetes mellitus and other diseases; Mini-Mental State Examination and tests of memory and executive function; ADLs. RESULTS: Executive and visuospatial functions were more impaired in individuals with diabetes mellitus than in those without, as assessed using Block Design (mean score± standard deviation 17.1±8.6 vs 20.5±9.6, P=.003) and Trails B (median seconds to accomplish the task: 255 vs 201, P=.03). For memory, word retention score was lower in those with diabetes mellitus than without (39.1±28.9 vs 48.0±29.7, P=.01), but the other memory tests did not show a difference between these two subgroups. More individuals with diabetes mellitus suffered from depressive symptoms than those without (55% vs 42%, P=.03). The ADL scores of those with diabetes mellitus were higher than those without. CONCLUSION: The pattern of cognitive deficits in people with diabetes mellitus suggests frontal-subcortical dysfunction, as seen in microvascular disease of the brain. The impairment in ADLs may be associated with this executive dysfunction, which cerebral microvascular disease in diabetes mellitus may cause.

Original languageEnglish (US)
Pages (from-to)496-501
Number of pages6
JournalJournal of the American Geriatrics Society
Volume54
Issue number3
DOIs
StatePublished - Mar 2006
Externally publishedYes

Fingerprint

Diabetes Mellitus
Activities of Daily Living
Executive Function
Brain Diseases
Demography
Depression
Population

Keywords

  • Cognition
  • Daily function
  • Diabetes mellitus
  • Executive

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Qiao Qiu, W., Lyn Price, L., Hibberd, P., Buell, J., Collins, L., Leins, D., ... Folstein, M. (2006). Executive dysfunction in homebound older people with diabetes mellitus. Journal of the American Geriatrics Society, 54(3), 496-501. https://doi.org/10.1111/j.1532-5415.2005.00632.x

Executive dysfunction in homebound older people with diabetes mellitus. / Qiao Qiu, Wei; Lyn Price, Lori; Hibberd, Patricia; Buell, Jennifer; Collins, Lauren; Leins, Drew; Mkaya Mwamburi, David; Rosenberg, Irwin; Smaldone, Lauren; Scott, Tammy M.; Siegel, Richard D.; Summergrad, Paul; Sun, Xiaoyan; Wagner, Carey; Wang, Lixia; Yee, Jacqueline; Tucker, Katherine L.; Folstein, Marshal.

In: Journal of the American Geriatrics Society, Vol. 54, No. 3, 03.2006, p. 496-501.

Research output: Contribution to journalArticle

Qiao Qiu, W, Lyn Price, L, Hibberd, P, Buell, J, Collins, L, Leins, D, Mkaya Mwamburi, D, Rosenberg, I, Smaldone, L, Scott, TM, Siegel, RD, Summergrad, P, Sun, X, Wagner, C, Wang, L, Yee, J, Tucker, KL & Folstein, M 2006, 'Executive dysfunction in homebound older people with diabetes mellitus', Journal of the American Geriatrics Society, vol. 54, no. 3, pp. 496-501. https://doi.org/10.1111/j.1532-5415.2005.00632.x
Qiao Qiu, Wei ; Lyn Price, Lori ; Hibberd, Patricia ; Buell, Jennifer ; Collins, Lauren ; Leins, Drew ; Mkaya Mwamburi, David ; Rosenberg, Irwin ; Smaldone, Lauren ; Scott, Tammy M. ; Siegel, Richard D. ; Summergrad, Paul ; Sun, Xiaoyan ; Wagner, Carey ; Wang, Lixia ; Yee, Jacqueline ; Tucker, Katherine L. ; Folstein, Marshal. / Executive dysfunction in homebound older people with diabetes mellitus. In: Journal of the American Geriatrics Society. 2006 ; Vol. 54, No. 3. pp. 496-501.
@article{08e7a912399d40f7bd78e10fe9adce08,
title = "Executive dysfunction in homebound older people with diabetes mellitus",
abstract = "OBJECTIVES: To describe patterns of cognitive deficits and activities of daily living (ADLs) in older people with diabetes mellitus. DESIGN: Cross-sectional, population-based study. SETTING: Three homecare agency areas in Boston, Massachusetts. PARTICIPANTS: Two hundred ninety-one homebound people aged 60 and older; 40{\%} with diabetes mellitus. MEASUREMENTS: Demographic data; evidence of diabetes mellitus and other diseases; Mini-Mental State Examination and tests of memory and executive function; ADLs. RESULTS: Executive and visuospatial functions were more impaired in individuals with diabetes mellitus than in those without, as assessed using Block Design (mean score± standard deviation 17.1±8.6 vs 20.5±9.6, P=.003) and Trails B (median seconds to accomplish the task: 255 vs 201, P=.03). For memory, word retention score was lower in those with diabetes mellitus than without (39.1±28.9 vs 48.0±29.7, P=.01), but the other memory tests did not show a difference between these two subgroups. More individuals with diabetes mellitus suffered from depressive symptoms than those without (55{\%} vs 42{\%}, P=.03). The ADL scores of those with diabetes mellitus were higher than those without. CONCLUSION: The pattern of cognitive deficits in people with diabetes mellitus suggests frontal-subcortical dysfunction, as seen in microvascular disease of the brain. The impairment in ADLs may be associated with this executive dysfunction, which cerebral microvascular disease in diabetes mellitus may cause.",
keywords = "Cognition, Daily function, Diabetes mellitus, Executive",
author = "{Qiao Qiu}, Wei and {Lyn Price}, Lori and Patricia Hibberd and Jennifer Buell and Lauren Collins and Drew Leins and {Mkaya Mwamburi}, David and Irwin Rosenberg and Lauren Smaldone and Scott, {Tammy M.} and Siegel, {Richard D.} and Paul Summergrad and Xiaoyan Sun and Carey Wagner and Lixia Wang and Jacqueline Yee and Tucker, {Katherine L.} and Marshal Folstein",
year = "2006",
month = "3",
doi = "10.1111/j.1532-5415.2005.00632.x",
language = "English (US)",
volume = "54",
pages = "496--501",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Executive dysfunction in homebound older people with diabetes mellitus

AU - Qiao Qiu, Wei

AU - Lyn Price, Lori

AU - Hibberd, Patricia

AU - Buell, Jennifer

AU - Collins, Lauren

AU - Leins, Drew

AU - Mkaya Mwamburi, David

AU - Rosenberg, Irwin

AU - Smaldone, Lauren

AU - Scott, Tammy M.

AU - Siegel, Richard D.

AU - Summergrad, Paul

AU - Sun, Xiaoyan

AU - Wagner, Carey

AU - Wang, Lixia

AU - Yee, Jacqueline

AU - Tucker, Katherine L.

AU - Folstein, Marshal

PY - 2006/3

Y1 - 2006/3

N2 - OBJECTIVES: To describe patterns of cognitive deficits and activities of daily living (ADLs) in older people with diabetes mellitus. DESIGN: Cross-sectional, population-based study. SETTING: Three homecare agency areas in Boston, Massachusetts. PARTICIPANTS: Two hundred ninety-one homebound people aged 60 and older; 40% with diabetes mellitus. MEASUREMENTS: Demographic data; evidence of diabetes mellitus and other diseases; Mini-Mental State Examination and tests of memory and executive function; ADLs. RESULTS: Executive and visuospatial functions were more impaired in individuals with diabetes mellitus than in those without, as assessed using Block Design (mean score± standard deviation 17.1±8.6 vs 20.5±9.6, P=.003) and Trails B (median seconds to accomplish the task: 255 vs 201, P=.03). For memory, word retention score was lower in those with diabetes mellitus than without (39.1±28.9 vs 48.0±29.7, P=.01), but the other memory tests did not show a difference between these two subgroups. More individuals with diabetes mellitus suffered from depressive symptoms than those without (55% vs 42%, P=.03). The ADL scores of those with diabetes mellitus were higher than those without. CONCLUSION: The pattern of cognitive deficits in people with diabetes mellitus suggests frontal-subcortical dysfunction, as seen in microvascular disease of the brain. The impairment in ADLs may be associated with this executive dysfunction, which cerebral microvascular disease in diabetes mellitus may cause.

AB - OBJECTIVES: To describe patterns of cognitive deficits and activities of daily living (ADLs) in older people with diabetes mellitus. DESIGN: Cross-sectional, population-based study. SETTING: Three homecare agency areas in Boston, Massachusetts. PARTICIPANTS: Two hundred ninety-one homebound people aged 60 and older; 40% with diabetes mellitus. MEASUREMENTS: Demographic data; evidence of diabetes mellitus and other diseases; Mini-Mental State Examination and tests of memory and executive function; ADLs. RESULTS: Executive and visuospatial functions were more impaired in individuals with diabetes mellitus than in those without, as assessed using Block Design (mean score± standard deviation 17.1±8.6 vs 20.5±9.6, P=.003) and Trails B (median seconds to accomplish the task: 255 vs 201, P=.03). For memory, word retention score was lower in those with diabetes mellitus than without (39.1±28.9 vs 48.0±29.7, P=.01), but the other memory tests did not show a difference between these two subgroups. More individuals with diabetes mellitus suffered from depressive symptoms than those without (55% vs 42%, P=.03). The ADL scores of those with diabetes mellitus were higher than those without. CONCLUSION: The pattern of cognitive deficits in people with diabetes mellitus suggests frontal-subcortical dysfunction, as seen in microvascular disease of the brain. The impairment in ADLs may be associated with this executive dysfunction, which cerebral microvascular disease in diabetes mellitus may cause.

KW - Cognition

KW - Daily function

KW - Diabetes mellitus

KW - Executive

UR - http://www.scopus.com/inward/record.url?scp=33644662081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644662081&partnerID=8YFLogxK

U2 - 10.1111/j.1532-5415.2005.00632.x

DO - 10.1111/j.1532-5415.2005.00632.x

M3 - Article

C2 - 16551319

AN - SCOPUS:33644662081

VL - 54

SP - 496

EP - 501

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 3

ER -