Exclusion of identified LGMD 1 loci from four dominant limb-girdle muscular dystrophy families

Marcy C. Speer, Jeffery M Vance, Felicia Lennon-Graham, Jeffrey M. Stajich, Kristi D. Viles, James M. Gilchrist, Vincenzo Nigro, Robert McMichael, Jerry G. Chutkow, Lucia Bartoloni, Steven K. Horrigan, Carol A. Westbrook, Margaret A Pericak-Vance

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The limb-girdle muscular dystrophies are a clinically and genetically heterogeneous group of disorders. Recent linkage analyses and positional cloning studies have identified numerous loci responsible for the recessive and dominant forms, underscoring the inherent heterogeneity. In this report, we investigate four large autosomal dominant limb-girdle pedigrees and exclude these pedigrees from linkage to these loci. In addition, there is no evidence for linkage to any of the seven recessive LGMD loci.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalHuman Heredity
Volume48
Issue number4
DOIs
StatePublished - Jul 1 1998
Externally publishedYes

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Keywords

  • Exclusion
  • Limb-girdle muscular dystrophy

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Speer, M. C., Vance, J. M., Lennon-Graham, F., Stajich, J. M., Viles, K. D., Gilchrist, J. M., Nigro, V., McMichael, R., Chutkow, J. G., Bartoloni, L., Horrigan, S. K., Westbrook, C. A., & Pericak-Vance, M. A. (1998). Exclusion of identified LGMD 1 loci from four dominant limb-girdle muscular dystrophy families. Human Heredity, 48(4), 179-184. https://doi.org/10.1159/000022799