Excessive muscular fatigue in the postpoliomyelitis syndrome

Khema R Sharma, J. Kent-Braun, M. A. Mynhier, M. W. Weiner, R. G. Miller

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

To investigate anterior tibial muscle fatigability and metabolism in postpoliomyelitis syndrome patients and controls, we performed measurements of force and relaxation time, as well as 31P magnetic resonance spectroscopy, during intermittent, low-intensity, isometric, voluntary exercise. Both maximum voluntary contraction and tetanic force declined significantly more during exercise and subsequently recovered less in patients compared with controls, indicating greater fatigue in patients. However, intracellular pH and phosphocreatine were not different in the two groups at rest or during exercise or recovery, suggesting that the greater fatigue of the patients was not due to an excessive change of metabolites. Moreover, the pre-exercise half-relaxation time of the tetanus was significantly prolonged in patients compared with controls, and the decline in tetanic force during exercise was linearly related to the half-relaxation time of tetanus, suggesting impaired calcium kinetics. Taken together, the findings of increased fatigability, delayed recovery, and prolonged half- relaxation time, without differences in metabolites, suggest that the fatigue in postpoliomyelitis syndrome may be due to impaired activation beyond the muscle membrane.

Original languageEnglish
Pages (from-to)642-646
Number of pages5
JournalNeurology
Volume44
Issue number4
StatePublished - Apr 1 1994
Externally publishedYes

Fingerprint

Postpoliomyelitis Syndrome
Muscle Fatigue
Exercise
Fatigue
Tetanus
Phosphocreatine
Skeletal Muscle
Magnetic Resonance Spectroscopy
Calcium
Muscles
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sharma, K. R., Kent-Braun, J., Mynhier, M. A., Weiner, M. W., & Miller, R. G. (1994). Excessive muscular fatigue in the postpoliomyelitis syndrome. Neurology, 44(4), 642-646.

Excessive muscular fatigue in the postpoliomyelitis syndrome. / Sharma, Khema R; Kent-Braun, J.; Mynhier, M. A.; Weiner, M. W.; Miller, R. G.

In: Neurology, Vol. 44, No. 4, 01.04.1994, p. 642-646.

Research output: Contribution to journalArticle

Sharma, KR, Kent-Braun, J, Mynhier, MA, Weiner, MW & Miller, RG 1994, 'Excessive muscular fatigue in the postpoliomyelitis syndrome', Neurology, vol. 44, no. 4, pp. 642-646.
Sharma KR, Kent-Braun J, Mynhier MA, Weiner MW, Miller RG. Excessive muscular fatigue in the postpoliomyelitis syndrome. Neurology. 1994 Apr 1;44(4):642-646.
Sharma, Khema R ; Kent-Braun, J. ; Mynhier, M. A. ; Weiner, M. W. ; Miller, R. G. / Excessive muscular fatigue in the postpoliomyelitis syndrome. In: Neurology. 1994 ; Vol. 44, No. 4. pp. 642-646.
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