Examination of seven candidate regions for multiple sclerosis: Strong evidence of linkage to chromosome 1q44

S. J. Kenealy, L. A. Herrel, Y. Bradford, N. Schnetz-Boutaud, J. R. Oksenberg, S. L. Hauser, L. F. Barcellos, S. Schmidt, S. G. Gregory, M. A. Pericak-Vance, Jonathan L. Haines

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Multiple sclerosis (MS) is a debilitating neuroimmunological and neurodegenerative disease with a strong genetic component. Numerous studies have failed to consistently identify genes that confer disease susceptibility except for association with HLA-DR. Seven non-HLA regions (1q, 2q, 9q, 13q, 16q, 18p and 19q) identified in a recent genomic screen were investigated by genotyping ∼20 single-nucleotide polymorphisms (SNPs) at ∼1 Mb intervals. Non-parametric multipoint analyses identified a peak LOD* score of 2.99 for the 1q44 region and substantially narrowed the linkage peak to ∼7 Mb. Ordered subset analyses (OSA) identified significant LOD score increases for 2q35 and 18p11 when ranking families by HLA-DR status and identified a significant LOD score increase in region 2q35 when ranking families by linkage to chromosome 1q44. 1q44 is particularly interesting because of linkage evidence for this region in studies of both rheumatoid arthritis and systemic lupus erythematosus.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalGenes and Immunity
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

Keywords

  • Chromosome 1q
  • Multiple sclerosis, linkage
  • Ordered subset analysis
  • SNPs

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

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    Kenealy, S. J., Herrel, L. A., Bradford, Y., Schnetz-Boutaud, N., Oksenberg, J. R., Hauser, S. L., Barcellos, L. F., Schmidt, S., Gregory, S. G., Pericak-Vance, M. A., & Haines, J. L. (2006). Examination of seven candidate regions for multiple sclerosis: Strong evidence of linkage to chromosome 1q44. Genes and Immunity, 7(1), 73-76. https://doi.org/10.1038/sj.gene.6364275