Exaggerated platelet reactivity in major depression

Dominique Musselman, Aaron Tomer, Amita K. Manatunga, Bettina T. Knight, Maryfrances R. Porter, Suha Kasey, Ulla Marzec, Laurence A. Harker, Charles Nemeroff

Research output: Contribution to journalArticle

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Abstract

Objective: This study investigated whether depressed patients exhibit exaggerated platelet reactivity. Method: In vivo platelet activation, secretion, and dose-response aggregation were measured in 12 depressed patients and eight normal comparison subjects after overnight bed rest and following orthostatic challenge. Results: The depressed patients exhibited increased platelet activation at baseline, demonstrated by increased binding of monoclonal antibody (moAb) annexin V protein reacting with prothrombinase complex binding sites. Following orthostatic challenge, the depressed patients exhibited increases in binding of moAbs PAC1 and anti-LIBS1 against activated glycoprotein IIb/IIIa and GE12 against P-selectin expressed upon secretion. The normal comparison subjects exhibited increases in platelet activation only with GE12. Conclusions: Depressed patients exhibit enhanced baseline platelet activation and responsiveness in comparison with normal subjects. Heightened susceptibility to platelet activation may be a mechanism by which depression is a significant risk factor for ischemic heart and cerebrovascular disease and/or mortality after myocardial infarction.

Original languageEnglish
Pages (from-to)1313-1317
Number of pages5
JournalAmerican Journal of Psychiatry
Volume153
Issue number10
StatePublished - Oct 1 1996
Externally publishedYes

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Platelet Activation
Blood Platelets
Cerebrovascular Disorders
Bed Rest
Platelet Glycoprotein GPIIb-IIIa Complex
P-Selectin
Annexin A5
Myocardial Ischemia
Myocardial Infarction
Binding Sites
Monoclonal Antibodies
Mortality
Proteins

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Musselman, D., Tomer, A., Manatunga, A. K., Knight, B. T., Porter, M. R., Kasey, S., ... Nemeroff, C. (1996). Exaggerated platelet reactivity in major depression. American Journal of Psychiatry, 153(10), 1313-1317.

Exaggerated platelet reactivity in major depression. / Musselman, Dominique; Tomer, Aaron; Manatunga, Amita K.; Knight, Bettina T.; Porter, Maryfrances R.; Kasey, Suha; Marzec, Ulla; Harker, Laurence A.; Nemeroff, Charles.

In: American Journal of Psychiatry, Vol. 153, No. 10, 01.10.1996, p. 1313-1317.

Research output: Contribution to journalArticle

Musselman, D, Tomer, A, Manatunga, AK, Knight, BT, Porter, MR, Kasey, S, Marzec, U, Harker, LA & Nemeroff, C 1996, 'Exaggerated platelet reactivity in major depression', American Journal of Psychiatry, vol. 153, no. 10, pp. 1313-1317.
Musselman D, Tomer A, Manatunga AK, Knight BT, Porter MR, Kasey S et al. Exaggerated platelet reactivity in major depression. American Journal of Psychiatry. 1996 Oct 1;153(10):1313-1317.
Musselman, Dominique ; Tomer, Aaron ; Manatunga, Amita K. ; Knight, Bettina T. ; Porter, Maryfrances R. ; Kasey, Suha ; Marzec, Ulla ; Harker, Laurence A. ; Nemeroff, Charles. / Exaggerated platelet reactivity in major depression. In: American Journal of Psychiatry. 1996 ; Vol. 153, No. 10. pp. 1313-1317.
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