Ex vivo high-resolution magnetic resonance imaging of the brain in Joubert's syndrome

Kyle R. Padgett, Bernard L. Maria, Anthony T. Yachnis, Stephen J. Blackband

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


This study employs ex vivo high-resolution magnetic resonance imaging (MRI) to examine anatomic structures in an intact brain of a child with Joubert's syndrome. Several of the specific hindbrain malformations associated with Joubert's syndrome are well resolved with ex vivo MRI, including the "molar tooth sign," which arises from enlarged and maloriented superior cerebellar peduncles, hypoplastic vermis, and deepening of the interpeduncular fossa. Superior resolution was achieved compared with that of in vivo MRI and included visualization of the inferior olives. One high-resolution study also showed that the decreased width of the brainstem isthmus is probably caused by failure of superior cerebellar peduncles to cross the midline at that level. The results of this study suggest that high-resolution MRI may be useful in screening the brainstem for malformations that can be studied histologicaly in a much more targeted fashion.

Original languageEnglish (US)
Pages (from-to)911-913
Number of pages3
JournalJournal of child neurology
Issue number12
StatePublished - Dec 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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