TY - JOUR
T1 - Ex vivo high-resolution magnetic resonance imaging of the brain in Joubert's syndrome
AU - Padgett, Kyle R.
AU - Maria, Bernard L.
AU - Yachnis, Anthony T.
AU - Blackband, Stephen J.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - This study employs ex vivo high-resolution magnetic resonance imaging (MRI) to examine anatomic structures in an intact brain of a child with Joubert's syndrome. Several of the specific hindbrain malformations associated with Joubert's syndrome are well resolved with ex vivo MRI, including the "molar tooth sign," which arises from enlarged and maloriented superior cerebellar peduncles, hypoplastic vermis, and deepening of the interpeduncular fossa. Superior resolution was achieved compared with that of in vivo MRI and included visualization of the inferior olives. One high-resolution study also showed that the decreased width of the brainstem isthmus is probably caused by failure of superior cerebellar peduncles to cross the midline at that level. The results of this study suggest that high-resolution MRI may be useful in screening the brainstem for malformations that can be studied histologicaly in a much more targeted fashion.
AB - This study employs ex vivo high-resolution magnetic resonance imaging (MRI) to examine anatomic structures in an intact brain of a child with Joubert's syndrome. Several of the specific hindbrain malformations associated with Joubert's syndrome are well resolved with ex vivo MRI, including the "molar tooth sign," which arises from enlarged and maloriented superior cerebellar peduncles, hypoplastic vermis, and deepening of the interpeduncular fossa. Superior resolution was achieved compared with that of in vivo MRI and included visualization of the inferior olives. One high-resolution study also showed that the decreased width of the brainstem isthmus is probably caused by failure of superior cerebellar peduncles to cross the midline at that level. The results of this study suggest that high-resolution MRI may be useful in screening the brainstem for malformations that can be studied histologicaly in a much more targeted fashion.
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U2 - 10.1177/08830738020170123003
DO - 10.1177/08830738020170123003
M3 - Article
C2 - 12593466
AN - SCOPUS:0037003049
VL - 17
SP - 911
EP - 913
JO - Journal of Child Neurology
JF - Journal of Child Neurology
SN - 0883-0738
IS - 12
ER -