Ex Vivo Expansion of Th2-Polarizing Immunotherapeutic iNKT Cells from Human Peripheral Blood

Natasha K. Khatwani, Kelly J. Andrews, Asha B. Pillai

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

iNKT cells, classified as innate lymphocytes with invariant TCRs, have been highlighted as a putative, “off-the-shelf” cellular immunotherapeutic strategy for the treatment of malignant and nonmalignant diseases. However, their paucity in human blood limits their immunotherapeutic applications. Herein we describe a rigorously optimized 21-day ex vivo expansion method to achieve log-fold increases in immunotherapeutic human iNKT cells.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages139-148
Number of pages10
DOIs
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
Volume2388
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Adoptive cellular therapy
  • Bone marrow transplantation
  • Cancer immunotherapy
  • Cytotoxicity
  • Hematopoietic stem cell transplantation
  • Immunotherapy
  • iNKT cells
  • Leukemia
  • NKT cells
  • Transplantation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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