Evolving role of surgical treatment in limited‐disease small cell lung carcinoma

Kasi S. Sridhar; Atif M. Hussein; Richard J. Thurer

doi:10.1002/jso.2930400305

Evolving role of surgical treatment in limited‐disease small cell lung carcinoma

Kasi S. Sridhar, Atif M. Hussein, Richard J. Thurer

Surgery

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The diagnostic role of surgical procedures in small cell lung carcinoma (SCLC) is well established. The therapeutic role of surgery has changed over the years. At present, curative resection is the treatment of choice in peripheral T_1-2 N(o)M(o) SCLC, and adjuvant chemotherapy may be beneficial. Surgery is also indicated in SCLC patients diagnosed by a limited pathologic sample in whom the clinical course suggests nonsmall cell lung carcinoma (NSCLC). The resection may reveal either a mixed tumor or an alternate diagnosis and may be potentially curative. Surgery, at the time of maximal response to chemotherapy in T₃N(o)M(o) SCLC, may be curative and reveal the presence of NSCLC elements. The best survival is in patients found to be tumor-free at surgery, and the worst survival is in N₂ patients.

Original language	English (US)
Pages (from-to)	155-161
Number of pages	7
Journal	Journal of surgical oncology
Volume	40
Issue number	3
DOIs	https://doi.org/10.1002/jso.2930400305
State	Published - Mar 1989

Keywords

adjuvant surgery
histologie conversion
mixed lung tumors
multimodality therapy
preoperative chemotherapy

ASJC Scopus subject areas

Surgery
Oncology

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10.1002/jso.2930400305

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title = "Evolving role of surgical treatment in limited‐disease small cell lung carcinoma",

abstract = "The diagnostic role of surgical procedures in small cell lung carcinoma (SCLC) is well established. The therapeutic role of surgery has changed over the years. At present, curative resection is the treatment of choice in peripheral T1-2 N(o)M(o) SCLC, and adjuvant chemotherapy may be beneficial. Surgery is also indicated in SCLC patients diagnosed by a limited pathologic sample in whom the clinical course suggests nonsmall cell lung carcinoma (NSCLC). The resection may reveal either a mixed tumor or an alternate diagnosis and may be potentially curative. Surgery, at the time of maximal response to chemotherapy in T3N(o)M(o) SCLC, may be curative and reveal the presence of NSCLC elements. The best survival is in patients found to be tumor-free at surgery, and the worst survival is in N2 patients.",

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N2 - The diagnostic role of surgical procedures in small cell lung carcinoma (SCLC) is well established. The therapeutic role of surgery has changed over the years. At present, curative resection is the treatment of choice in peripheral T1-2 N(o)M(o) SCLC, and adjuvant chemotherapy may be beneficial. Surgery is also indicated in SCLC patients diagnosed by a limited pathologic sample in whom the clinical course suggests nonsmall cell lung carcinoma (NSCLC). The resection may reveal either a mixed tumor or an alternate diagnosis and may be potentially curative. Surgery, at the time of maximal response to chemotherapy in T3N(o)M(o) SCLC, may be curative and reveal the presence of NSCLC elements. The best survival is in patients found to be tumor-free at surgery, and the worst survival is in N2 patients.

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