Evolving 'omics' technologies for diagnostics of head and neck cancer

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Squamous cell carcinoma of head and neck (SCCHN) is the sixth most common malignancy and is a major cause of cancer morbidity and mortality worldwide. As with most solid cancers, the cure rate for SCCHN is excellent if tumors are diagnosed early in the course of the disease. Early diagnosis of cancer remains difficult because of the lack of specific symptoms in early disease as well as the limited understanding of etiology and oncogenesis. Advances in proteomics and genomics contribute to the understanding of the pathophysiology of neoplasia, cancer diagnosis and anticancer drug discovery. The powerful 'omics' technologies have opened new avenues towards biomarker discovery, identification of signaling molecules associated with cell growth, cell death, cellular metabolism and early detection of cancer. Analysis of tumor-specific omics profiles provided a unique opportunity to diagnose, classify, and detect malignant disease; to better understand and define the behavior of specific tumors; and to provide direct and targeted therapy. These technologies however still require integration and standardization of techniques and validation against accepted clinical and pathologic parameters. This article provides a summary of technologies, potential clinical applications, and challenges of omics in head and neck cancer.

Original languageEnglish (US)
Pages (from-to)49-59
Number of pages11
JournalBriefings in Functional Genomics and Proteomics
Volume8
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

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Head and Neck Neoplasms
Tumors
Technology
Neoplasms
Cell growth
Biomarkers
Cell death
Metabolism
Standardization
Early Detection of Cancer
Molecules
Drug Discovery
Genomics
Proteomics
Carcinogenesis
Cell Death
Epithelial Cells
Morbidity
Mortality
Growth

Keywords

  • Genomics
  • Head and neck cancer
  • Metastasis
  • Omics
  • Proteomics

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology

Cite this

Evolving 'omics' technologies for diagnostics of head and neck cancer. / Nagathihalli, Nagaraj.

In: Briefings in Functional Genomics and Proteomics, Vol. 8, No. 1, 2009, p. 49-59.

Research output: Contribution to journalArticle

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