Evolving Evidence of Calreticulin as a Pharmacological Target in Neurological Disorders

Vignesh Kotian, Deepaneeta Sarmah, Harpreet Kaur, Radhika Kesharwani, Geetesh Verma, Leela Mounica, Pabbala Veeresh, Kiran Kalia, Anupom Borah, Xin Wang, Kunjan R. Dave, Dileep R. Yavagal, Pallab Bhattacharya

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Calreticulin (CALR), a lectin-like ER chaperone, was initially known only for its housekeeping function, but today it is recognized for many versatile roles in different compartments of a cell. Apart from canonical roles in protein folding and calcium homeostasis, it performs a variety of noncanonical roles, mostly in CNS development. In the past, studies have linked Calreticulin with various other biological components which are detrimental in deciding the fate of neurons. Many neurological disorders that differ in their etiology are commonly associated with aberrant levels of Calreticulin, that lead to modulation of apoptosis and phagocytosis, and impact on transcriptional pathways, impairment in proteostatis, and calcium imbalances. Such multifaceted properties of Calreticulin are the reason why it has been implicated in vital roles of the nervous system in recent years. Hence, understanding its role in the physiology of neurons would help to unearth its involvement in the spectrum of neurological disorders. This Review aims toward exploring the interplay of Calreticulin in neurological disorders which would aid in targeting Calreticulin for developing novel neurotherapeutics.

Original languageEnglish (US)
Pages (from-to)2629-2646
Number of pages18
JournalACS Chemical Neuroscience
Volume10
Issue number6
DOIs
StatePublished - Jun 19 2019

Keywords

  • Calreticulin
  • endoplasmic reticulum
  • neurological disorder
  • phagocytosis
  • proteostasis

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Cognitive Neuroscience
  • Cell Biology

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