Evolutionary conservation of motif constituents in the yeast protein interaction network

S. Wuchty, Z. Oltvai, A. L. Barabási

Research output: Contribution to journalArticlepeer-review

313 Scopus citations

Abstract

Understanding why some cellular components are conserved across species but others evolve rapidly is a key question of modern biology. Here we show that in Saccharomyces cerevisiae, proteins organized in cohesive patterns of interactions are conserved to a substantially higher degree than those that do not participate in such motifs. We find that the conservation of proteins in distinct topological motifs correlates with the interconnectedness and function of that motif and also depends on the structure of the overall interactome topology. These findings indicate that motifs may represent evolutionary conserved topological units of cellular networks molded in accordance with the specific biological function in which they participate.

Original languageEnglish (US)
Pages (from-to)176-179
Number of pages4
JournalNature genetics
Volume35
Issue number2
DOIs
StatePublished - Oct 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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