Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes

David Watkins, Zheng W. Chen, Austin L. Hughes, Mark G. Evans, Thomas F. Tedder, Norman L. Letvin

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

THE products of the classical human major histocompatibility complex (MHC) class I genes (HLA-A, -B, -C) are highly polymorphic molecules that bind peptides and present them to T lymphocytes1-4. The non-polymorphic, non-classical MHC class I gene products (HLA-E, -F, -G) are not restricting elements for the majority of T lymphocytes5-7. The evolutionary relationship of the non-classical and classical MHC class I genes is unclear. Here we present the cloning and sequencing of the MHC class I genes of a New World primate, the cotton-top tamarin (Saguinus oedipus). The expressed MHC class I genes of this species are more closely related to the human non-classical HLA-G (ref. 7) gene than they are to genes of the human classical HLA-A, -B, and -C loci. These observations imply that classical and nonclassical genes do not necessarily constitute mutually exclusive groups over evolutionary time.

Original languageEnglish
Pages (from-to)60-63
Number of pages4
JournalNature
Volume346
Issue number6279
StatePublished - Jul 5 1990
Externally publishedYes

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MHC Class I Genes
Major Histocompatibility Complex
Primates
HLA-A Antigens
HLA-B Antigens
Genes
Saguinus
HLA-G Antigens
Organism Cloning
Peptides

ASJC Scopus subject areas

  • General

Cite this

Watkins, D., Chen, Z. W., Hughes, A. L., Evans, M. G., Tedder, T. F., & Letvin, N. L. (1990). Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. Nature, 346(6279), 60-63.

Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. / Watkins, David; Chen, Zheng W.; Hughes, Austin L.; Evans, Mark G.; Tedder, Thomas F.; Letvin, Norman L.

In: Nature, Vol. 346, No. 6279, 05.07.1990, p. 60-63.

Research output: Contribution to journalArticle

Watkins, D, Chen, ZW, Hughes, AL, Evans, MG, Tedder, TF & Letvin, NL 1990, 'Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes', Nature, vol. 346, no. 6279, pp. 60-63.
Watkins D, Chen ZW, Hughes AL, Evans MG, Tedder TF, Letvin NL. Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. Nature. 1990 Jul 5;346(6279):60-63.
Watkins, David ; Chen, Zheng W. ; Hughes, Austin L. ; Evans, Mark G. ; Tedder, Thomas F. ; Letvin, Norman L. / Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. In: Nature. 1990 ; Vol. 346, No. 6279. pp. 60-63.
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