Evolution of a new nonclassical MHC class I locus in two Old World primate species

Jonathan E. Boyson, Kristen K. Iwanaga, Julie A. Urvater, Austin L. Hughes, Thaddeus G. Golos, David Watkins

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

HLA-G is a nonclassical major histocompatibility complex (MHC) class I molecule that is expressed only in the human placenta, suggesting that it plays an important role at the fetal-maternal interface. In rhesus monkeys, which have similar placentation to humans, the HLA-G orthologue is a pseudogene. However, rhesus monkeys express a novel placental MHC class I molecule, Mamu-AG, which has HLA-G-like characteristics. Phylogenetic analysis of AG alleles in two Old World primate species, the baboon and the rhesus macaque, revealed limited diversity characteristic of a nonclassical MHC class I locus. Gene trees constructed using classical and nonclassical primate MHC class I alleles demonstrated that the AG locus was most closely related to the classical A locus. Interestingly, gene tree analyses suggested that the AG alleles were most closely related to a subset of A alleles which are the products of an ancestral interlocus recombination event between the A and B loci. Calculation of the rates of synonymous and nonsynonymous substitution at the AG locus revealed that positive selection was not acting on the codons encoding the peptide binding region. In exon 4, however, the rate of nonsynonymous substitution was significantly lower than the rate of synonymous substitution, suggesting that negative selection was acting on these codons.

Original languageEnglish
Pages (from-to)86-98
Number of pages13
JournalImmunogenetics
Volume49
Issue number2
DOIs
StatePublished - Jan 25 1999
Externally publishedYes

Fingerprint

HLA-G Antigens
Major Histocompatibility Complex
Primates
Macaca mulatta
Alleles
Codon
Placentation
Pseudogenes
Papio
Placenta
Genetic Recombination
Genes
Exons
Mothers
Peptides

Keywords

  • Evolution
  • MHC
  • Primates
  • Reproduction

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Boyson, J. E., Iwanaga, K. K., Urvater, J. A., Hughes, A. L., Golos, T. G., & Watkins, D. (1999). Evolution of a new nonclassical MHC class I locus in two Old World primate species. Immunogenetics, 49(2), 86-98. https://doi.org/10.1007/s002510050467

Evolution of a new nonclassical MHC class I locus in two Old World primate species. / Boyson, Jonathan E.; Iwanaga, Kristen K.; Urvater, Julie A.; Hughes, Austin L.; Golos, Thaddeus G.; Watkins, David.

In: Immunogenetics, Vol. 49, No. 2, 25.01.1999, p. 86-98.

Research output: Contribution to journalArticle

Boyson, JE, Iwanaga, KK, Urvater, JA, Hughes, AL, Golos, TG & Watkins, D 1999, 'Evolution of a new nonclassical MHC class I locus in two Old World primate species', Immunogenetics, vol. 49, no. 2, pp. 86-98. https://doi.org/10.1007/s002510050467
Boyson, Jonathan E. ; Iwanaga, Kristen K. ; Urvater, Julie A. ; Hughes, Austin L. ; Golos, Thaddeus G. ; Watkins, David. / Evolution of a new nonclassical MHC class I locus in two Old World primate species. In: Immunogenetics. 1999 ; Vol. 49, No. 2. pp. 86-98.
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