Evidence that axons are mitogenic for oligodendrocytes isolated from adult animals

Patrick Wood, R. P. Bunge

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Recovery from demyelinating events in the adult central nervous system (CNS) may depend in some situations on the generation, by cell division, of new oligodendrocytes (ODCs). Adult ODCs, identified by morphological criteria, have been shown to divide in vivo in response to induced demyelination or to physical trauma, although the factors that elicit this response are unknown. Adult ODCs do not proliferate in vitro under normal conditions (ref. 4 and P.M.W., unpublished observations). Encouraged by observations that axons provide a mitogenic stimulus for Schwann cells and support the proliferation of embryonic ODC progenitors, we have studied the response of adult ODCs, identified by immunocytological criteria, to axons of dorsal root ganglion neurones in culture. We have now found that adult ODCs proliferate in vitro when neurones are present but not when neurones are absent, suggesting that neurones can elicit ODC division under the conditions prevailing in our culture system.

Original languageEnglish
Pages (from-to)756-758
Number of pages3
JournalNature
Volume320
Issue number6064
StatePublished - Jan 1 1986
Externally publishedYes

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Oligodendroglia
Axons
Neurons
Schwann Cells
Spinal Ganglia
Demyelinating Diseases
Cell Division
Central Nervous System
Cell Proliferation
Wounds and Injuries

ASJC Scopus subject areas

  • General

Cite this

Evidence that axons are mitogenic for oligodendrocytes isolated from adult animals. / Wood, Patrick; Bunge, R. P.

In: Nature, Vol. 320, No. 6064, 01.01.1986, p. 756-758.

Research output: Contribution to journalArticle

Wood, P & Bunge, RP 1986, 'Evidence that axons are mitogenic for oligodendrocytes isolated from adult animals', Nature, vol. 320, no. 6064, pp. 756-758.
Wood, Patrick ; Bunge, R. P. / Evidence that axons are mitogenic for oligodendrocytes isolated from adult animals. In: Nature. 1986 ; Vol. 320, No. 6064. pp. 756-758.
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