Evidence of Increased Class I MHC Expression on Human Peripheral Blood Lymphocytes during Acute Ethanol Intoxication

Michael A. Kolber, Ron M. Walls, Marion L. Hinners, Dinah S. Singer

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Certain ethanol-related diseases in humans have been linked to disorders of immunity. Although humoral and cellular immunity have been studied, the precise mechanisms whereby ethanol use leads to tissue damage remain unknown. In order to explore the hypothesis that ethanol may lead to alteration in expression of tissue Class I major histocompatibility antigen causing an autoimmune phenomenon, a population of acutely ethanol-intoxicated patients was studied. Measurement of Class I major histocompatibility antigen on peripheral blood lymphocytes in this population showed a highly significant (p < 0.01) increase over controls. The role that this increased antigenicity may play in the evolution of clinical disease is discussed.

Original languageEnglish (US)
Pages (from-to)820-823
Number of pages4
JournalAlcoholism: Clinical and Experimental Research
Volume12
Issue number6
DOIs
StatePublished - Dec 1988
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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