Evidence of HIV-1 DNA in peritoneal effluent of children with HIV kephropathy on peritoneal dialysis

Jaus Struss, Guhton Zilleruelo

Research output: Contribution to journalArticle

Abstract

Children win HIV aephrcpathy (HIVN) who develoflEod Stafe Renal Disease (ESRD) leal to ba managed preferentially with chronic peritoneal dialysis. Although this modality poses lets risk of blood exposure to petieods tnd dialysis staff than hemodiilyiis, we have been concerned about the potertial infectiviy of peritaneal effluentsi. In order to answer question, we studied a group of four childrean (a age 8 years; range 4-19 years) with HIVN and ESRD on continuous cycling paritoncal dialysis (CCPD). HIV-1 DNA detectioa by PCR analysis was performed in limiltaoeauily obtained aamples of peripberal blood monoouclear cells and peritoneal effluents. All aamplei detected the pretence of HIV proviral DNA sequences, No correlation was found with the clinical status of HIV infected pattentt, absolute CD4 counts, number of cells in peritoeal rffliwii, or time elapsed since the start of dialysis. These results demonstrate that HIV infected cells are present in peritooeal effluents of children on continuous cycling peritooeal dialysis, even in the early states of HIV infection. Thus, universal precautions in dialysis units should be strictly enforced, emphasizing to proper disposal of potentially infective dialysale and, whenever possible, imtttitfinn of isolation procedures.

Original languageEnglish (US)
Number of pages1
JournalPediatric AIDS and HIV Infection
Volume7
Issue number4
StatePublished - Dec 1 1996

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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