Abstract
Idiopathic intracranial hypertension (IIH) is characterized by increased ICP without evidence for intracranial mass lesion. Although the pathogenesis remains unknown, some association was found with intracranial venous thrombosis. To our knowledge, the extracranial venous drainage was not systematically evaluated in these patients. This study compared extracranial cerebral venous outflow in eight IIH patients and eight control subjects using magnetic resonance (MR) Venography and flow measurements. In addition, the study identified extracranial factors that affect cerebral venous drainage. In six of the IIH patients, either complete or partial functional obstruction of the internal jugular veins (IJVs) coupled with increased venous outflow through secondary venous channels was documented. On average, a four-fold increase in mean venous flow rate through the epidural and/or vertebral veins was measured in IIH patients compared with the healthy subjects. In one of the healthy subjects, intracranial venous outflow was studied also during external compression of the IJVs. Over 40% of the venous outflow through the IJVs shifted to the epidural veins and intracranial pressure, measured noninvasively by MRI, increased from 7.5 to 13 mmHg. Findings from this study suggest that increased ICP in some IIH patients could be associated with increased extracranial resistance to cerebral venous outflow.
| Original language | English (US) |
|---|---|
| Title of host publication | Intracranial Pressure and Brain Monitoring XII |
| Publisher | Springer Wien |
| Pages | 129-132 |
| Number of pages | 4 |
| Edition | 95 |
| ISBN (Print) | 9783211243367 |
| DOIs | |
| State | Published - Jan 1 2005 |
| Externally published | Yes |
Publication series
| Name | Acta Neurochirurgica, Supplementum |
|---|---|
| Number | 95 |
| ISSN (Print) | 0065-1419 |
Fingerprint
Keywords
- effect of body posture on cerebral venous outflow
- extracranial cerebral venous drainage
- Idiopathic intracranial hypertension (IIH)
- MR venography
- vertebral venous plexus
ASJC Scopus subject areas
- Surgery
- Clinical Neurology
Cite this
Evidence for the importance of extracranial venous flow in patients with idiopathic intracranial hypertension (IIH). / Alperin, Noam; Lee, S. H.; Mazda, M.; Hushek, S. G.; Roitberg, B.; Goddwin, J.; Lichtor, T.
Intracranial Pressure and Brain Monitoring XII. 95. ed. Springer Wien, 2005. p. 129-132 (Acta Neurochirurgica, Supplementum; No. 95).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Evidence for the importance of extracranial venous flow in patients with idiopathic intracranial hypertension (IIH)
AU - Alperin, Noam
AU - Lee, S. H.
AU - Mazda, M.
AU - Hushek, S. G.
AU - Roitberg, B.
AU - Goddwin, J.
AU - Lichtor, T.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Idiopathic intracranial hypertension (IIH) is characterized by increased ICP without evidence for intracranial mass lesion. Although the pathogenesis remains unknown, some association was found with intracranial venous thrombosis. To our knowledge, the extracranial venous drainage was not systematically evaluated in these patients. This study compared extracranial cerebral venous outflow in eight IIH patients and eight control subjects using magnetic resonance (MR) Venography and flow measurements. In addition, the study identified extracranial factors that affect cerebral venous drainage. In six of the IIH patients, either complete or partial functional obstruction of the internal jugular veins (IJVs) coupled with increased venous outflow through secondary venous channels was documented. On average, a four-fold increase in mean venous flow rate through the epidural and/or vertebral veins was measured in IIH patients compared with the healthy subjects. In one of the healthy subjects, intracranial venous outflow was studied also during external compression of the IJVs. Over 40% of the venous outflow through the IJVs shifted to the epidural veins and intracranial pressure, measured noninvasively by MRI, increased from 7.5 to 13 mmHg. Findings from this study suggest that increased ICP in some IIH patients could be associated with increased extracranial resistance to cerebral venous outflow.
AB - Idiopathic intracranial hypertension (IIH) is characterized by increased ICP without evidence for intracranial mass lesion. Although the pathogenesis remains unknown, some association was found with intracranial venous thrombosis. To our knowledge, the extracranial venous drainage was not systematically evaluated in these patients. This study compared extracranial cerebral venous outflow in eight IIH patients and eight control subjects using magnetic resonance (MR) Venography and flow measurements. In addition, the study identified extracranial factors that affect cerebral venous drainage. In six of the IIH patients, either complete or partial functional obstruction of the internal jugular veins (IJVs) coupled with increased venous outflow through secondary venous channels was documented. On average, a four-fold increase in mean venous flow rate through the epidural and/or vertebral veins was measured in IIH patients compared with the healthy subjects. In one of the healthy subjects, intracranial venous outflow was studied also during external compression of the IJVs. Over 40% of the venous outflow through the IJVs shifted to the epidural veins and intracranial pressure, measured noninvasively by MRI, increased from 7.5 to 13 mmHg. Findings from this study suggest that increased ICP in some IIH patients could be associated with increased extracranial resistance to cerebral venous outflow.
KW - effect of body posture on cerebral venous outflow
KW - extracranial cerebral venous drainage
KW - Idiopathic intracranial hypertension (IIH)
KW - MR venography
KW - vertebral venous plexus
UR - http://www.scopus.com/inward/record.url?scp=85052610350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052610350&partnerID=8YFLogxK
U2 - 10.1007/3-211-32318-X_28
DO - 10.1007/3-211-32318-X_28
M3 - Conference contribution
C2 - 16463836
AN - SCOPUS:85052610350
SN - 9783211243367
T3 - Acta Neurochirurgica, Supplementum
SP - 129
EP - 132
BT - Intracranial Pressure and Brain Monitoring XII
PB - Springer Wien
ER -