Evidence for the importance of extracranial venous flow in patients with idiopathic intracranial hypertension (IIH)

Noam Alperin, S. H. Lee, M. Mazda, S. G. Hushek, B. Roitberg, J. Goddwin, T. Lichtor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

38 Citations (Scopus)

Abstract

Idiopathic intracranial hypertension (IIH) is characterized by increased ICP without evidence for intracranial mass lesion. Although the pathogenesis remains unknown, some association was found with intracranial venous thrombosis. To our knowledge, the extracranial venous drainage was not systematically evaluated in these patients. This study compared extracranial cerebral venous outflow in eight IIH patients and eight control subjects using magnetic resonance (MR) Venography and flow measurements. In addition, the study identified extracranial factors that affect cerebral venous drainage. In six of the IIH patients, either complete or partial functional obstruction of the internal jugular veins (IJVs) coupled with increased venous outflow through secondary venous channels was documented. On average, a four-fold increase in mean venous flow rate through the epidural and/or vertebral veins was measured in IIH patients compared with the healthy subjects. In one of the healthy subjects, intracranial venous outflow was studied also during external compression of the IJVs. Over 40% of the venous outflow through the IJVs shifted to the epidural veins and intracranial pressure, measured noninvasively by MRI, increased from 7.5 to 13 mmHg. Findings from this study suggest that increased ICP in some IIH patients could be associated with increased extracranial resistance to cerebral venous outflow.

Original languageEnglish (US)
Title of host publicationIntracranial Pressure and Brain Monitoring XII
PublisherSpringer Wien
Pages129-132
Number of pages4
Edition95
ISBN (Print)9783211243367
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Publication series

NameActa Neurochirurgica, Supplementum
Number95
ISSN (Print)0065-1419

Fingerprint

Pseudotumor Cerebri
Jugular Veins
Drainage
Veins
Healthy Volunteers
Intracranial Thrombosis
Phlebography
Intracranial Pressure
Venous Thrombosis
Magnetic Resonance Spectroscopy

Keywords

  • effect of body posture on cerebral venous outflow
  • extracranial cerebral venous drainage
  • Idiopathic intracranial hypertension (IIH)
  • MR venography
  • vertebral venous plexus

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Alperin, N., Lee, S. H., Mazda, M., Hushek, S. G., Roitberg, B., Goddwin, J., & Lichtor, T. (2005). Evidence for the importance of extracranial venous flow in patients with idiopathic intracranial hypertension (IIH). In Intracranial Pressure and Brain Monitoring XII (95 ed., pp. 129-132). (Acta Neurochirurgica, Supplementum; No. 95). Springer Wien. https://doi.org/10.1007/3-211-32318-X_28

Evidence for the importance of extracranial venous flow in patients with idiopathic intracranial hypertension (IIH). / Alperin, Noam; Lee, S. H.; Mazda, M.; Hushek, S. G.; Roitberg, B.; Goddwin, J.; Lichtor, T.

Intracranial Pressure and Brain Monitoring XII. 95. ed. Springer Wien, 2005. p. 129-132 (Acta Neurochirurgica, Supplementum; No. 95).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Alperin, N, Lee, SH, Mazda, M, Hushek, SG, Roitberg, B, Goddwin, J & Lichtor, T 2005, Evidence for the importance of extracranial venous flow in patients with idiopathic intracranial hypertension (IIH). in Intracranial Pressure and Brain Monitoring XII. 95 edn, Acta Neurochirurgica, Supplementum, no. 95, Springer Wien, pp. 129-132. https://doi.org/10.1007/3-211-32318-X_28
Alperin N, Lee SH, Mazda M, Hushek SG, Roitberg B, Goddwin J et al. Evidence for the importance of extracranial venous flow in patients with idiopathic intracranial hypertension (IIH). In Intracranial Pressure and Brain Monitoring XII. 95 ed. Springer Wien. 2005. p. 129-132. (Acta Neurochirurgica, Supplementum; 95). https://doi.org/10.1007/3-211-32318-X_28
Alperin, Noam ; Lee, S. H. ; Mazda, M. ; Hushek, S. G. ; Roitberg, B. ; Goddwin, J. ; Lichtor, T. / Evidence for the importance of extracranial venous flow in patients with idiopathic intracranial hypertension (IIH). Intracranial Pressure and Brain Monitoring XII. 95. ed. Springer Wien, 2005. pp. 129-132 (Acta Neurochirurgica, Supplementum; 95).
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